DNAA_CAUSK
ID DNAA_CAUSK Reviewed; 487 AA.
AC B0T135;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=Caul_0001;
OS Caulobacter sp. (strain K31).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter; unclassified Caulobacter.
OX NCBI_TaxID=366602;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K31;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T.,
RA Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Kim E., Stephens C., Richardson P.;
RT "Complete sequence of chromosome of Caulobacter sp. K31.";
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC {ECO:0000255|HAMAP-Rule:MF_00377}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC Rule:MF_00377}.
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DR EMBL; CP000927; ABZ69139.1; -; Genomic_DNA.
DR RefSeq; WP_012284097.1; NC_010338.1.
DR AlphaFoldDB; B0T135; -.
DR SMR; B0T135; -.
DR STRING; 366602.Caul_0001; -.
DR EnsemblBacteria; ABZ69139; ABZ69139; Caul_0001.
DR KEGG; cak:Caul_0001; -.
DR eggNOG; COG0593; Bacteria.
DR HOGENOM; CLU_026910_3_0_5; -.
DR OMA; REFNPLF; -.
DR OrthoDB; 219876at2; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT CHAIN 1..487
FT /note="Chromosomal replication initiator protein DnaA"
FT /id="PRO_1000079941"
FT BINDING 186..193
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ SEQUENCE 487 AA; 53790 MW; 75447173A4CDD37C CRC64;
MTIKGGVVSQ DFSAAFSTVA CEPAGVVWNK VCTVLKRELG DAAFGSWIAP AVLREGPSGD
VVVVTPTGIA RDWIRRSAWR RVSELWTAND ATGRRLDLKS RLEFESVGGA GYEAKAEPIE
IVLPVSSDVP ALAPTNGSKP SPVQGLQERF TFDTFVPGPA NEFAHAVARR VASWADGHFN
PVLFHGPYGF GKTHLLNALA WEAMRQAPTK RVVYLTAERF LSTFVRAVMD RQTAAFKEEL
RGADLLIIDD VHFIAGKQSS QEELFHTLTA LVEDGRRVVF SSDRAPAAMT EMDARLRSHL
SAGLVCGLEP ADRALRIGIL ERKLQALSRQ HGFEPTLRAE VLNFLADRFT DSVRELEGAL
NTLSARAGEG VSRLTLEEVQ AILRPHLRAG EKRITIDDIQ KATSEHYGMK QVDLLSERRN
RAIARPRQAA MWLAKQLTTR SLPDIGRRFG GRDHTTVLHA VRRIEALRAD DPVLSQDLET
ITRKLRG