ID   DNAA_CAUVN              Reviewed;         490 AA.
AC   B8GWW5; P35887;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=CCNA_00008;
OS   Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=565050;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8288535; DOI=10.1128/jb.176.2.401-408.1994;
RA   Zweiger G., Shapiro L.;
RT   "Expression of Caulobacter dnaA as a function of the cell cycle.";
RL   J. Bacteriol. 176:401-408(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=20472802; DOI=10.1128/jb.00255-10;
RA   Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA   Walunas T.L., Crosson S.;
RT   "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL   J. Bacteriol. 192:3678-3688(2010).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; U01667; AAA18927.1; -; Genomic_DNA.
DR   EMBL; CP001340; ACL93475.1; -; Genomic_DNA.
DR   PIR; B36947; B36947.
DR   RefSeq; WP_010917898.1; NC_011916.1.
DR   RefSeq; YP_002515383.1; NC_011916.1.
DR   AlphaFoldDB; B8GWW5; -.
DR   SMR; B8GWW5; -.
DR   PRIDE; B8GWW5; -.
DR   EnsemblBacteria; ACL93475; ACL93475; CCNA_00008.
DR   GeneID; 7333149; -.
DR   KEGG; ccs:CCNA_00008; -.
DR   PATRIC; fig|565050.3.peg.8; -.
DR   HOGENOM; CLU_026910_3_0_5; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; 219876at2; -.
DR   PhylomeDB; B8GWW5; -.
DR   Proteomes; UP000001364; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..490
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000378284"
FT   BINDING         189..196
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        334
FT                   /note="H -> L (in Ref. 1; AAA18927)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   490 AA;  53884 MW;  33BD9484340B5DC1 CRC64;
     MTMKGGVASQ DFSAAIATAC EPAANVWSKV CVALKRELGD AAFGSWIAPA MLREAATGDV
     VLVTSTGIAR DWIRRSAWRR IGELWAAHDA TGRRIDLKSR LEFEAAAGAY VEATPKAVAA
     EPIEIVLPVS TDAPTVVAPS AKSPRTQGLQ ERFTFETFVP GPANEFAHAV ARRIANWADG
     HFNPVLFHGP YGFGKTHLLN ALAWEAMRNA PEKRVVYLTA ERFLSTFVRA VMDRQTAAFK
     EELRAADLLI IDDVHFIAGK QSTQEELFHT LTALVGEGGR VVFSADRPPS AMTEMDAHLR
     SHLSAGLVCG LEPADRNLRL GILERKIQTL GAAHGFEPSI RPEVMQFLAD RFTDSVRELE
     GALNTLSARA GEGLSRMTLD EVQAILRPHL RSGEKRITID DIQKATAEHY GMKQADLLSE
     RRNRAVARPR QAAMWLAKQL TTRSLPDIGR RFGGRDHTTV LHAVRRIEAL RAEDSALSHD
     LETLTRKLRG