ID   DNAA_CORGB              Reviewed;         524 AA.
AC   A4Q9R9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=cgR_0001;
OS   Corynebacterium glutamicum (strain R).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=340322;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R;
RX   PubMed=17379713; DOI=10.1099/mic.0.2006/003657-0;
RA   Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M.,
RA   Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.;
RT   "Comparative analysis of the Corynebacterium glutamicum group and complete
RT   genome sequence of strain R.";
RL   Microbiology 153:1042-1058(2007).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
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DR   EMBL; AP009044; BAF52962.1; -; Genomic_DNA.
DR   RefSeq; WP_003855327.1; NC_009342.1.
DR   AlphaFoldDB; A4Q9R9; -.
DR   SMR; A4Q9R9; -.
DR   EnsemblBacteria; BAF52962; BAF52962; cgR_0001.
DR   GeneID; 58309769; -.
DR   KEGG; cgt:cgR_0001; -.
DR   HOGENOM; CLU_026910_2_0_11; -.
DR   OMA; REFNPLF; -.
DR   PhylomeDB; A4Q9R9; -.
DR   Proteomes; UP000006698; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..524
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_1000048640"
FT   REGION          95..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         224..231
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   524 AA;  58436 MW;  716511FE95B05BEC CRC64;
     MSQNSSSLLE TWRQVVADLT TLSQQADSGF DPLTPTQRAY LNLTKPIAIV DGYAVLSTPN
     AMAKNVIEND LGDALTRVLS LRMGRSFSLA VSVEPEQEIP ETPAQQEFKY QPDAPVISSN
     KAPKQYEVGG RGGASTSDGW ERTHSAPAPE PHPAPIADPE PELATPQRIP RETPAHNPNR
     EVSLNPKYTF ESFVIGPFNR FANAAAVAVA ESPAKAFNPL FISGGSGLGK THLLHAVGNY
     AQELQPGLRI KYVSSEEFTN DYINSVRDDR QETFKRRYRN LDILMVDDIQ FLAGKEGTQE
     EFFHTFNALH QADKQIILSS DRPPKQLTTL EDRLRTRFEG GLITDIQPPD LETRIAILMK
     KAQTDGTHVD REVLELIASR FESSIRELEG ALIRVSAYSS LINQPIDKEM AIVALRDILP
     EPEDMEITAP VIMEVTAEYF EISVDTLRGA GKTRAVAHAR QLAMYLCREL TDMSLPKIGD
     VFGGKDHTTV MYADRKIRQE MTEKRDTYDE IQQLTQLIKS RGRN