DNAA_EHRRG
ID DNAA_EHRRG Reviewed; 464 AA.
AC Q5FHH8;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN OrderedLocusNames=ERGA_CDS_02880;
OS Ehrlichia ruminantium (strain Gardel).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Ehrlichia.
OX NCBI_TaxID=302409;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Gardel;
RX PubMed=16547041; DOI=10.1128/jb.188.7.2533-2542.2006;
RA Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y.,
RA Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.;
RT "Comparative genomic analysis of three strains of Ehrlichia ruminantium
RT reveals an active process of genome size plasticity.";
RL J. Bacteriol. 188:2533-2542(2006).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC {ECO:0000255|HAMAP-Rule:MF_00377}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC Rule:MF_00377}.
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DR EMBL; CR925677; CAI27740.1; -; Genomic_DNA.
DR RefSeq; WP_011154971.1; NC_006831.1.
DR AlphaFoldDB; Q5FHH8; -.
DR SMR; Q5FHH8; -.
DR EnsemblBacteria; CAI27740; CAI27740; ERGA_CDS_02880.
DR GeneID; 56785012; -.
DR KEGG; erg:ERGA_CDS_02880; -.
DR HOGENOM; CLU_026910_3_0_5; -.
DR OMA; REFNPLF; -.
DR OrthoDB; 219876at2; -.
DR BioCyc; ERUM302409:ERGA_RS01485-MON; -.
DR Proteomes; UP000000533; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT CHAIN 1..464
FT /note="Chromosomal replication initiator protein DnaA"
FT /id="PRO_0000114176"
FT BINDING 170..177
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ SEQUENCE 464 AA; 52675 MW; E87D303D94EC069C CRC64;
MNNDNTEVLE NYPQDGLQSN SHIIWKGIQS RLHKFYGNAI YDSWLSVLLY VSTESGKVLL
SAPTRFIKEW ILVHYLDQIL KYWQDEDQSI CSVDICVVSN QDPNLLVDIK DRVDRGIKGN
CDNVSSPLDP RFTFDNFVVG KPNELAFAAA RRVAESNSPI SGSNPLFLYG GVGLGKTHLM
HAIAWYIIKS CSKRKIAYLS AEKFMYQYVT ALRSKDIMLF KEQFRSVDIL MVDDVQFISG
KDSTQEEFFH TFNALIDQNK QLVISADRSP SDLDGVEERI KSRLGWGLVA DINETTFELR
LGILQLKVEK MGINIPNKVL EFLAKNIKSN IRELEGALNK VVAHSSLVGC SITLDTASDI
LSDLLRANHK SVTLECIQKK VAEFFNIKVS DMYSTRRLRT LARPRQIAMY LSKKLTQKSL
PEIGKSFGGR DHATVIHAVK QIEKLMDTDS KLRDDINLLN RMLR