ID   DNAA_FRATT              Reviewed;         491 AA.
AC   Q5NIQ8;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=FTT_0001;
OS   Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=177416;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCHU S4 / Schu 4;
RX   PubMed=15640799; DOI=10.1038/ng1499;
RA   Larsson P., Oyston P.C.F., Chain P., Chu M.C., Duffield M., Fuxelius H.-H.,
RA   Garcia E., Haelltorp G., Johansson D., Isherwood K.E., Karp P.D.,
RA   Larsson E., Liu Y., Michell S., Prior J., Prior R., Malfatti S.,
RA   Sjoestedt A., Svensson K., Thompson N., Vergez L., Wagg J.K., Wren B.W.,
RA   Lindler L.E., Andersson S.G.E., Forsman M., Titball R.W.;
RT   "The complete genome sequence of Francisella tularensis, the causative
RT   agent of tularemia.";
RL   Nat. Genet. 37:153-159(2005).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG44634.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AJ749949; CAG44634.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011997492.1; NZ_CP010290.1.
DR   RefSeq; YP_169084.1; NC_006570.2.
DR   AlphaFoldDB; Q5NIQ8; -.
DR   SMR; Q5NIQ8; -.
DR   STRING; 177416.FTT_0001; -.
DR   DNASU; 3191523; -.
DR   EnsemblBacteria; CAG44634; CAG44634; FTT_0001.
DR   GeneID; 60806127; -.
DR   KEGG; ftu:FTT_0001; -.
DR   PATRIC; fig|177416.18.peg.1; -.
DR   eggNOG; COG0593; Bacteria.
DR   Proteomes; UP000001174; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..491
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114180"
FT   BINDING         196..203
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   491 AA;  55814 MW;  F581F704C5537396 CRC64;
     MTTWDKCLKK IKKNLSTFEY KTWIKPIHVE QNSNLFTVYC NNEYFKKHIK SKYGNLILST
     IQECHGNDLI IEYSNKKFSG EKITEVITAG PQANFFSTTS VEIKDESEDT KVVQEPKISK
     KSNSKDFSSS QELFGFDEAM LITAKEDEEY SFGLPLKEKY VFDSFVVGDA NKIARAAAMQ
     VSINPGKLHN PLFIYGGSGL GKTHLMQAIG NHAREVNPNA KIIYTNSEQF IKDYVNSIRL
     QDQDEFQRVY RSADILLIDD IQFIAGKEGT AQEFFHTFNA LYENGKQIIL TSDKYPNEIE
     GLEERLVSRF GYGLTVSVDM PDLETRIAIL LKKAHDLGQK LPNETAAFIA ENVRTNVREL
     EGALNRVLTT SKFNHKDPTI EVAQACLRDV IKIQEKKVKI DNIQKVVADF YRIRVKDLTS
     NQRSRNIARP RQIAMSLARE LTSHSLPEIG NAFGGRDHTT VMHAVKAITK LRQSNTSISD
     DYELLLDKIS R