ID   DNAA_HELPJ              Reviewed;         457 AA.
AC   Q9ZJ96;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=jhp_1417;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; AE001439; AAD06996.1; -; Genomic_DNA.
DR   PIR; E71809; E71809.
DR   RefSeq; WP_000380659.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZJ96; -.
DR   SMR; Q9ZJ96; -.
DR   STRING; 85963.jhp_1417; -.
DR   EnsemblBacteria; AAD06996; AAD06996; jhp_1417.
DR   KEGG; hpj:jhp_1417; -.
DR   PATRIC; fig|85963.30.peg.1130; -.
DR   eggNOG; COG0593; Bacteria.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..457
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114189"
FT   BINDING         150..157
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   457 AA;  51800 MW;  38B3B9EACE318615 CRC64;
     MDTNNNIEKE ILALVKQNPK VSLIEYENYL SQLKYNPNAS KSDIAFFYAP NKFLCTTITA
     KYGALLKEIL SQNKVGMHLA HSVDVRIEVA PKIQVNAQSN INYKATKTSV KDSYTFENFV
     VGSCNNTVYE IAKKVAQSDT PPYNPVLFYG GTGLGKTHIL NAIGNHALEK HKKVVLVTSE
     DFLTDFLKHL DNKNMDSFKK KYRHCDFFLL DDAQFLQGKP KLEEEFFHTF NELHANSKQI
     VLISDRSPKN IAGLEDRLKS RFEWGITAKV MPPDLETKLS IVKQKCQLNK ITLPEEVMEY
     IAQHISDNIR QMEGAIIKIS VNANLMNATI DLNLAKTVLE DLQKDHAEGS SLENILLAVA
     QSLNLKSSEI KVSSRQKNVA LARKLVVYFA RLYTPNPTLS LAQFLDLKDH SSISKMYSSV
     KKMLEEEKSP FILSLREEIK NRLNELNDKK TAFNSSE