DNAA_HELPY
ID DNAA_HELPY Reviewed; 457 AA.
AC O26057;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Chromosomal replication initiator protein DnaA;
GN Name=dnaA; OrderedLocusNames=HP_1529;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC O26057; O25828: HP_1230; NbExp=14; IntAct=EBI-527994, EBI-527984;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR EMBL; AE000511; AAD08568.1; -; Genomic_DNA.
DR PIR; A64711; A64711.
DR RefSeq; NP_208319.1; NC_000915.1.
DR RefSeq; WP_000380647.1; NC_018939.1.
DR PDB; 2WP0; X-ray; 2.67 A; C/D=1-112.
DR PDBsum; 2WP0; -.
DR AlphaFoldDB; O26057; -.
DR SMR; O26057; -.
DR DIP; DIP-3596N; -.
DR IntAct; O26057; 3.
DR MINT; O26057; -.
DR STRING; 85962.C694_07920; -.
DR PaxDb; O26057; -.
DR EnsemblBacteria; AAD08568; AAD08568; HP_1529.
DR KEGG; hpy:HP_1529; -.
DR PATRIC; fig|85962.47.peg.1644; -.
DR eggNOG; COG0593; Bacteria.
DR OMA; REFNPLF; -.
DR PhylomeDB; O26057; -.
DR EvolutionaryTrace; O26057; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0006260; P:DNA replication; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Cytoplasm; DNA replication; DNA-binding;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..457
FT /note="Chromosomal replication initiator protein DnaA"
FT /id="PRO_0000114188"
FT BINDING 150..157
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT HELIX 7..10
FT /evidence="ECO:0007829|PDB:2WP0"
FT HELIX 11..16
FT /evidence="ECO:0007829|PDB:2WP0"
FT HELIX 23..28
FT /evidence="ECO:0007829|PDB:2WP0"
FT HELIX 30..32
FT /evidence="ECO:0007829|PDB:2WP0"
FT STRAND 37..39
FT /evidence="ECO:0007829|PDB:2WP0"
FT STRAND 42..51
FT /evidence="ECO:0007829|PDB:2WP0"
FT HELIX 52..71
FT /evidence="ECO:0007829|PDB:2WP0"
FT STRAND 84..89
FT /evidence="ECO:0007829|PDB:2WP0"
SQ SEQUENCE 457 AA; 51683 MW; 975B30C9AB3A3C97 CRC64;
MDTNNNIEKE ILALVKQNPK VSLIEYENYF SQLKYNPNAS KSDIAFFYAP NQVLCTTITA
KYGALLKEIL SQNKVGMHLA HSVDVRIEVA PKIQINAQSN INYKAIKTSV KDSYTFENFV
VGSCNNTVYE IAKKVAQSDT PPYNPVLFYG GTGLGKTHIL NAIGNHALEK HKKVVLVTSE
DFLTDFLKHL DNKTMDSFKA KYRHCDFFLL DDAQFLQGKP KLEEEFFHTF NELHANSKQI
VLISDRSPKN IAGLEDRLKS RFEWGITAKV MPPDLETKLS IVKQKCQLNQ ITLPEEVMEY
IAQHISDNIR QMEGAIIKIS VNANLMNASI DLNLAKTVLE DLQKDHAEGS SLENILLAVA
QSLNLKSSEI KVSSRQKNVA LARKLVVYFA RLYTPNPTLS LAQFLDLKDH SSISKMYSGV
KKMLEEEKSP FVLSLREEIK NRLNELNDKK TAFNSSE
