ID   DNAA_LACLA              Reviewed;         455 AA.
AC   Q9CJJ2;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=LL0001; ORFNames=L0274;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; AE005176; AAK04099.1; -; Genomic_DNA.
DR   PIR; A86625; A86625.
DR   RefSeq; NP_266157.1; NC_002662.1.
DR   RefSeq; WP_010905022.1; NC_002662.1.
DR   AlphaFoldDB; Q9CJJ2; -.
DR   SMR; Q9CJJ2; -.
DR   STRING; 272623.L0274; -.
DR   PaxDb; Q9CJJ2; -.
DR   EnsemblBacteria; AAK04099; AAK04099; L0274.
DR   GeneID; 60355495; -.
DR   KEGG; lla:L0274; -.
DR   PATRIC; fig|272623.7.peg.1; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_3_2_9; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..455
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114193"
FT   BINDING         158..165
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   455 AA;  51461 MW;  A5434E694E57084E CRC64;
     MASLNENQKF WARVTELAQQ SIGKQAYDFF IEPAQLMSVE QDTANILLDS GMKKDYWKKQ
     SDLITTAGFE VFGRMIDYEL YANDELTELE LHRLNNQSSI EEQPRSTAKP ASPLVSGLNE
     KYNFENFVQG PGNRWTLAAA IAVADKPGDT YNPLFIYGGA GLGKTHLMHA IGNQILTDNP
     TARIKYVSSE NFVNDYVNAT RKNQMENFEN TYRNLDLLLL DDVQFFSDKE GTKNEFFNTF
     NALYDKGSQI VLTSDRIPQE LNNLEDRLVS RFSWGLTTDI TAPDYETRMA ILLIKSESSR
     LEFPSETLSY IAGQIDSNVR ELEGALNRVE FVARANGIAV VDIETASQAL RSLKNATQQS
     LSNLTIKKIQ DEVANYYHIS FSDLVGPKRP KEIAFPRQIA MYLVRELLGT SLPAIGTAFG
     GRDHTTVMYA YKQISDKMKN DMDVQKDIDS IKRKF