DNAA_LEPCP
ID DNAA_LEPCP Reviewed; 510 AA.
AC B1Y547;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=Lcho_0001;
OS Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix
OS discophora (strain SP-6)).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Leptothrix.
OX NCBI_TaxID=395495;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51168 / LMG 8142 / SP-6;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Emerson D., Richardson P.;
RT "Complete sequence of Leptothrix cholodnii SP-6.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC {ECO:0000255|HAMAP-Rule:MF_00377}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC Rule:MF_00377}.
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DR EMBL; CP001013; ACB32277.1; -; Genomic_DNA.
DR RefSeq; WP_012345039.1; NC_010524.1.
DR AlphaFoldDB; B1Y547; -.
DR SMR; B1Y547; -.
DR STRING; 395495.Lcho_0001; -.
DR EnsemblBacteria; ACB32277; ACB32277; Lcho_0001.
DR KEGG; lch:Lcho_0001; -.
DR eggNOG; COG0593; Bacteria.
DR HOGENOM; CLU_026910_0_1_4; -.
DR OMA; REFNPLF; -.
DR OrthoDB; 219876at2; -.
DR Proteomes; UP000001693; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..510
FT /note="Chromosomal replication initiator protein DnaA"
FT /id="PRO_1000121996"
FT REGION 125..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 215..222
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ SEQUENCE 510 AA; 55914 MW; A07DD34841A02041 CRC64;
MHTDLWERGC ERLAAELPEQ QFNTWIRPLP PADVTLAGDG VLVGLRVPNR FKLDWIRAQY
GSRIEATLSE LAGKPVRLEL SLLPRDAVAR AQGMAAAPAA QAGAAPQPTQ SPMAIGAALH
AAATARHDPQ SVVPTPGGSA NGRAAPRVGE PGGPVGTSTL PVAPTLSPAV SRGRLNPALT
FDTLVPGRAN QMARTAALHV VGAPGHMYNP LFIYGGVGLG KTHLIHAVGN ALIRDNPDAR
VLYLHAEQFI SDVVRNYQRK TFDELKAKYH SLDLLLIDDV QFFAGKDRTQ EEFFNAFEAL
LAKRAHIIMT SDTYPKGLVD IDERLTSRFD AGLTVAIEPP ELEMRVAILM KKSDAEGSRM
PEDVAFFVAK NVRANVRELE GALRKVLAYS RFSHKEISIN LAREALKDLL SIQNRQVSVE
NIQKTVADFY KIKIADMYSK KRPASIARPR QIAMYLAKEM TQKSLPEIGE LFGGRDHTTV
LHAVRKIGGE RQKNTELNQQ LHVLEQTLKG