ID   DNAA_MESFL              Reviewed;         443 AA.
AC   Q6F2A9;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=Mfl001;
OS   Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1)
OS   (Acholeplasma florum).
OC   Bacteria; Tenericutes; Mollicutes; Entomoplasmatales; Entomoplasmataceae;
OC   Mesoplasma.
OX   NCBI_TaxID=265311;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33453 / NBRC 100688 / NCTC 11704 / L1;
RA   Birren B.W., Stange-Thomann N., Hafez N., DeCaprio D., Fisher S.,
RA   Butler J., Elkins T., Kodira C.D., Major J., Wang S., Nicol R., Nusbaum C.;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
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DR   EMBL; AE017263; AAT75357.1; -; Genomic_DNA.
DR   RefSeq; WP_011182898.1; NC_006055.1.
DR   RefSeq; YP_053241.1; NC_006055.1.
DR   AlphaFoldDB; Q6F2A9; -.
DR   SMR; Q6F2A9; -.
DR   STRING; 265311.Mfl001; -.
DR   EnsemblBacteria; AAT75357; AAT75357; Mfl001.
DR   GeneID; 2897662; -.
DR   KEGG; mfl:Mfl001; -.
DR   PATRIC; fig|265311.5.peg.1; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_3_2_14; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000006647; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..443
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114205"
FT   BINDING         142..149
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   443 AA;  50263 MW;  F0B9AF49504EBE19 CRC64;
     METKALWEKL INKLKKEKLI DQDIIEEYIV TSELIKISNT EFVILVRSNL GVTILNEFKE
     VFVYEFKSVL NSYVSVDFLT KEIFEKNTKK ENKKEPINTV LSENALTFEN FIVGSSNKQA
     NLAAKNVVAN PGMSFNPLFI YGDSGLGKTH LLQAIKNQAE LNGKKVLYLT SEEFTKRIVN
     ALNKGDLSEI EELKTEINSN EFFILDDVQF LSKKDKTNEF FFNIINNFTE NGKQLVFSSD
     KTPELLNGFD KRMITRFNSG LSTPINALDI PTAKLIIEAE IKKQGLKQKI KEDAVVYLAQ
     NFSDDVRKIK GLVNRLLFFG IQNDLGHIID LEDVIDLFKD TPSANLGLLN VKKIKEVVAK
     KYDVTIKAID GKARTTAIKN ARHLSMYFAK IILNHTSTQI GAEFGGRDHS TVLSAISRIE
     KLIYKEKEFK KIVESLKNEI IGK