DNAA_MICLU
ID DNAA_MICLU Reviewed; 515 AA.
AC P21173;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Chromosomal replication initiator protein DnaA;
GN Name=dnaA;
OS Micrococcus luteus (Micrococcus lysodeikticus).
OC Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Micrococcus.
OX NCBI_TaxID=1270;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2172090; DOI=10.1016/0378-1119(90)90138-h;
RA Fujita M.Q., Yoshikawa H., Ogasawara N.;
RT "Structure of the dnaA region of Micrococcus luteus: conservation and
RT variations among eubacteria.";
RL Gene 93:73-78(1990).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR EMBL; M34006; AAA25315.1; -; Genomic_DNA.
DR PIR; JQ0739; IQMCL.
DR RefSeq; WP_012750665.1; NZ_NAQZ01000014.1.
DR AlphaFoldDB; P21173; -.
DR SMR; P21173; -.
DR STRING; 1232675.GCA_000309825_00063; -.
DR PATRIC; fig|1270.31.peg.1; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT CHAIN 1..515
FT /note="Chromosomal replication initiator protein DnaA"
FT /id="PRO_0000114207"
FT REGION 90..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 214..221
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 515 AA; 56876 MW; CE4130730C390FCA CRC64;
MVADQAVLSS WRSVVGSLED DARVSARLMG FVYLAQPQGL IGNTLLLAVP NETTRETLQG
TQVADALTDA LTQEFREEIL LAISIDANLQ PPRTPSSEAR RSSLAGGPSG AAAPDVELPP
AATAATSRRA VAEELPGFRI EPPADVVPAA NAAPNGNGKP TPAPPSTSAE TSRLNDRYHF
ETFVIGSSNR FAHAAANAVA EAPAKAYNPL FIYGESGLGK THLLHAIGHY ARRLYPGLRV
RYVNSEEFTN DFINSIRHDE GASFKQVYRN VDILLIDDIQ FLADKEATVE EFFHTFNTLY
NNNKQVVITS DLPPKQLSGF EDRLRSRFEW GLITDIQPPD LETRIAILRK KAEAEGLVAP
PEALEYIASR ISTNIRELEG ALIRVTAFAS LNRQTVDIEL AEHVLKDLIT DETAHEITPE
LILHATGEYF NLTLEELTSK SRTRTLVTAR QIAMYLLREL TEMSLPKIGQ VLGGRDHTTV
IHADRKIREL MAERRTIYNQ VTELTNEIKR KQRGA
