ID   DNAA_MYCAV              Reviewed;         508 AA.
AC   P49990;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA;
OS   Mycobacterium avium.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=1764;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Rajagopalan M.;
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 214-474.
RX   PubMed=7557482; DOI=10.1016/0378-1119(95)00403-s;
RA   Rajagopalan M., Qin M.H., Steingrube V.A., Nash D.R., Wallace R.J. Jr.,
RA   Madiraju M.V.V.S.;
RT   "Amplification and cloning of the Mycobacterium tuberculosis dnaA gene.";
RL   Gene 163:75-79(1995).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; U19185; AAC83390.1; -; Genomic_DNA.
DR   PIR; PC4083; PC4083.
DR   AlphaFoldDB; P49990; -.
DR   SMR; P49990; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..508
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114209"
FT   REGION          104..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         209..216
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   508 AA;  56797 MW;  88EBE940ABA4A2BB CRC64;
     MADDPGSSFT TVWNAVVSEL NGEPVADAEP NRTTLVTPLT PQQRAWLNLV RPLTIVEGFA
     LLSVPSSFVQ NEIERHLRAP ITDALSRRLG QQIQLGVRIA PPPDDVEDAL IPSAEPFPDT
     DADLSARRRT DSRASGERGA VTNTQPGWTN YFTERPHAID PAVAAGTSLN RRYTFDTFVI
     GASNRFAHAA VLAIAEAPAR AYNPLFIWGE SGLGKTHLLH AAGNYAQRFF PGMRVKYVST
     EEFTNDFINS LRDDRKVPFK RTIRDVDVLL VDDIQFIEGK EGIQEEFFHT FNTLHNANKQ
     IVISSDRPPK QLATLEDRLR TRFEWGLITD VQPPELETRI AILRKKAQME RLAVPDDVLE
     LIASSIERNI RELEGALIRV TAFASLNKTP IDKSLAEIVL RDLIADASTM QISAATIMAA
     TAEYFDTTVV ELRGPGKTRA LAQSRQIAMY LCRELTDLSL PKIGQAFGRD HTTLMYGQRK
     ILSEMAERRG GFDHVKELTT RIRQRSKR