ID   DNAA_MYCCT              Reviewed;         450 AA.
AC   P24116; Q2STB2; Q48990; Q9R632;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=MCAP_0001;
OS   Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343
OS   / NCTC 10154).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=340047;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1544573; DOI=10.1016/0378-1119(92)90439-v;
RA   Fujita M.Q., Yoshikawa H., Ogasawara N.;
RT   "Structure of the dnaA and DnaA-box region in the Mycoplasma capricolum
RT   chromosome: conservation and variations in the course of evolution.";
RL   Gene 110:17-23(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1779750; DOI=10.1111/j.1365-2958.1991.tb01967.x;
RA   Yoshikawa H., Ogasawara N.;
RT   "Structure and function of DnaA and the DnaA-box in eubacteria:
RT   evolutionary relationships of bacterial replication origins.";
RL   Mol. Microbiol. 5:2589-2597(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=California kid / ATCC 27343 / NCTC 10154;
RA   Glass J.I., Lartigue C., Pfannkoch C., Baden-Tillson H., Smith H.O.,
RA   Venter J.C., Roske K., Wise K.S., Calcutt M.J., Nelson W.C., Nierman W.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-43.
RX   PubMed=9170268; DOI=10.1016/s0378-1097(97)00121-3;
RA   Seto S., Murata S., Miyata M.;
RT   "Characterization of dnaA gene expression in Mycoplasma capricolum.";
RL   FEMS Microbiol. Lett. 150:239-247(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 181-420.
RC   STRAIN=California kid / ATCC 27343 / NCTC 10154;
RX   PubMed=7476192; DOI=10.1111/j.1365-2958.1995.tb02321.x;
RA   Bork P., Ouzounis C., Casari G., Schneider R., Sander C., Dolan M.,
RA   Gilbert W., Gillevet P.M.;
RT   "Exploring the Mycoplasma capricolum genome: a minimal cell reveals its
RT   physiology.";
RL   Mol. Microbiol. 16:955-967(1995).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; D90426; BAA14415.1; -; Genomic_DNA.
DR   EMBL; CP000123; ABC01518.1; -; Genomic_DNA.
DR   EMBL; AB000401; BAA20470.1; -; Genomic_DNA.
DR   EMBL; Z33057; CAA83731.2; -; Genomic_DNA.
DR   PIR; JN0272; IQYMC.
DR   RefSeq; WP_011386906.1; NC_007633.1.
DR   AlphaFoldDB; P24116; -.
DR   SMR; P24116; -.
DR   EnsemblBacteria; ABC01518; ABC01518; MCAP_0001.
DR   GeneID; 23778213; -.
DR   KEGG; mcp:MCAP_0001; -.
DR   HOGENOM; CLU_026910_3_2_14; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; 219876at2; -.
DR   PhylomeDB; P24116; -.
DR   Proteomes; UP000001928; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..450
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114208"
FT   BINDING         148..155
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        260
FT                   /note="L -> I (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        418..420
FT                   /note="TVI -> NSY (in Ref. 5)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   450 AA;  51765 MW;  98FCED45F214B39D CRC64;
     MNLNDILKEL KLSLIANKNI DESVYNDYIK TINIYKKDLS NYVVVVKSQF GLLAIKQFRP
     TIENEIKKIL KQPVNISFTY EQEYQKQLEK TESINKDHSD IISKKNKKVN ENTFENFVIG
     SSNEQAFIAV QTVSKNPGIS YNPLFIYGES GMGKTHLLKA AKNYIESNFS DLKVSYMSGD
     EFARKAVDIL QKTHKEIEQF KNEVCQNDVL IIDDVQFLSY KEKTNEIFFT IFNNFIENDK
     QLFFSSDKSP ELLNGFDNRL ITRFNMGLSI AIQKLDNKTA TAIIKKEIKN QNIKTEVTNE
     AINFISNYYS DDVRKIKGSV SRLNFWSQQN PEEKVITIEI ISDLFRDIPT SKLGILNVKK
     IKEVVSEKYG ISVNAIDGKA RSKSIVTARH IAMYLTKEIL NHTLAQIGEE FGGRDHTTVI
     NAERKIEMML KKDKQLKKTV DILKNKILTK