ID   DNAA_MYCLE              Reviewed;         502 AA.
AC   P46388;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 3.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=ML0001;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8969512; DOI=10.1099/13500872-142-11-3147;
RA   Fsihi H., de Rossi E., Salazar L., Cantoni R., Labo M., Riccardi G.,
RA   Takiff H.E., Eiglmeier K., Bergh S., Cole S.T.;
RT   "Gene arrangement and organization in an approximately 76 kb fragment
RT   encompassing the oriC region of the chromosome of Mycobacterium leprae.";
RL   Microbiology 142:3147-3161(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB53141.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAC29509.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L39923; AAB53141.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL583917; CAC29509.1; ALT_INIT; Genomic_DNA.
DR   PIR; A86909; A86909.
DR   RefSeq; WP_010907454.1; NC_002677.1.
DR   AlphaFoldDB; P46388; -.
DR   SMR; P46388; -.
DR   STRING; 272631.ML0001; -.
DR   EnsemblBacteria; CAC29509; CAC29509; CAC29509.
DR   KEGG; mle:ML0001; -.
DR   Leproma; ML0001; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_2_0_11; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..502
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114212"
FT   BINDING         203..210
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        183
FT                   /note="A -> R (in Ref. 1; AAB53141)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   502 AA;  56314 MW;  2D45721D99DEDEAE CRC64;
     MADDLSLGFT TVWNAVVSEL NGESNTDDEA TNDSTLVTPL TPQQRAWLNL VQPLTIIEGF
     ALLSVPSSFV QNEIERHLRT PITDALSRRL GQQIQLGVRI APPSTDHIDD NSSSADVLLT
     DDCGTDTDEN YGEPLTGEYQ GLPTYFTERP HHTESTVTGG TSLNRRYTFE TFVIGASNRF
     AHAAALAIAE APARAYNPLF IWGESGLGKT HLLHAAGNYA QRLFPGMRVK YVSTEEFTND
     FINSLRDDRK VAFKRSYRDV DVLLVDDIQF IEGKEGIQEE FFHTFNTLHN ANKQIVISSD
     RPPKQLATLE DRLRTRFEWG LITDVQPPEL ETRIAILRKK AQMERLAVPG DVLELIASSI
     ERNIRELEGA LIRVTAFASL NKTAIDKALA EIVLRDLIAD ASTMQISAAT IMTATAEYFD
     TTIEELRGPG KTRALAQSRQ IAMYLCRELT DLSLPKIGQA FGRDHTTVMY AQRKILSEMA
     ERREVFDHVK ELTTRIRQRS KR