ID   DNAA_MYCMS              Reviewed;         450 AA.
AC   Q6MUM7;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=MSC_0001;
OS   Mycoplasma mycoides subsp. mycoides SC (strain PG1).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PG1;
RX   PubMed=14762060; DOI=10.1101/gr.1673304;
RA   Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J.,
RA   Johansson K.-E., Pettersson B., Uhlen M.;
RT   "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain
RT   PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP).";
RL   Genome Res. 14:221-227(2004).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAE76654.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BX293980; CAE76654.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_975012.1; NC_005364.2.
DR   AlphaFoldDB; Q6MUM7; -.
DR   SMR; Q6MUM7; -.
DR   STRING; 272632.MSC_0001; -.
DR   EnsemblBacteria; CAE76654; CAE76654; MSC_0001.
DR   KEGG; mmy:MSC_0001; -.
DR   PATRIC; fig|272632.4.peg.1; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_3_2_14; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000001016; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..450
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114213"
FT   BINDING         148..155
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   450 AA;  51755 MW;  78179DE6583A0A54 CRC64;
     MNVNDILKEL KLNLMANKNI DESVYNDYIK TINIHKKGFS DYIVVVKSQF GLLAIKQFRQ
     TIKNEIKNIL KEPVNISFTY EQEYKKQLEK DELIKKDHSD IITKKVKKIN ENTFENFVIG
     ASNEQAFIAV QTVSKNPGIS YNPLFIYGES GMGKTHLLKA AKNYIESNFS DLKVSYMSGD
     EFARKAVDIL QKTHKEIEQF KNKICQNDVL IIDDVQFLSY KEKTNEIFFT IFNNFIENDK
     QLFFSSDKSP ELLNGFDNRL ITRFNMGLSI AIQKLDNKTA TAIIKKEIKN QNIKSEVTSE
     AINFISNYYS DDVRKIKGSV SRLNFWSQQN PEEKIITIEI VSDLFRDIPT SKLGILNVKK
     IKEVVSEKYG ISVNAIDGKA RSKSIVTARH IAMFLTKEIL NHTLAQIGEE FGGRDHTTVI
     NAERKIETML KKDKQLKKTV DILKNKILTK