ID   DNAA_MYCPA              Reviewed;         509 AA.
AC   Q9L7L7;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=MAP_0001;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Zhang Q., Kapur V.;
RT   "Genomic organization of the Mycobacterium avium subsp. paratuberculosis
RT   origin of replication region.";
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; AF222789; AAF33692.1; -; Genomic_DNA.
DR   EMBL; AE016958; AAS02318.1; -; Genomic_DNA.
DR   RefSeq; WP_010948690.1; NC_002944.2.
DR   AlphaFoldDB; Q9L7L7; -.
DR   SMR; Q9L7L7; -.
DR   STRING; 262316.MAP_0001; -.
DR   EnsemblBacteria; AAS02318; AAS02318; MAP_0001.
DR   KEGG; mpa:MAP_0001; -.
DR   PATRIC; fig|262316.17.peg.2; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_2_0_11; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..509
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114215"
FT   REGION          99..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         210..217
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   509 AA;  56620 MW;  2472F3F644D34EC9 CRC64;
     MADDPGSSFT TVWNAVVSEL NGEPVADGGA ANRTTLVTPL TPQQRAWLNL VRPLTIVEGF
     ALLSVPSSFV QNEIERHLRA PITDALSRRL GQQIQLGVRI APPPDDVEDA PIPPAEPFPD
     TDAALSADDG ADGEPVENGE PVTDTQPGWP NYFTERPHAI DPAVAAGTSL NRRYTFDTFV
     IGASNRFAHA AALAIAEAPA RAYNPLFIWG ESGLGKTHLL HAAGNYAQRL FPGMRVKYVS
     TEEFTNDFIN SLRDDRKVAF KRSYRDVDVL LVDDIQFIEG KEGIQEEFFH TFNTLHNANK
     QIVISSDRPP KQLATLEDRL RTRFEWGLIT DVQPPELETR IAILRKKAQM ERLAVPDDVL
     ELIASSIERN IRELEGALIR VTAFASLNKT PIDKSLAEIV LRDLIADAST MQISAATIMA
     ATAEYFDTTV EELRGPGKTR ALAQSRQIAM YLCRELTDLS LPKIGQAFGR DHTTVMYAQR
     KILSEMAERR EVFDHVKELT TRIRQRSKR