ID   DNAA_MYCSM              Reviewed;         504 AA.
AC   P0C557; P49992; Q59558;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA;
OS   Mycolicibacterium smegmatis (Mycobacterium smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=1772;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 607 / DSM 43465 / JCM 20379 / NBRC 3207 / NRRL B-692;
RX   PubMed=8733228; DOI=10.1111/j.1365-2958.1996.tb02617.x;
RA   Salazar L., Fsihi H., De Rossi E., Riccardi G., Rios C., Cole S.T.,
RA   Takiff H.E.;
RT   "Organization of the origins of replication of the chromosomes of
RT   Mycobacterium smegmatis, Mycobacterium leprae and Mycobacterium
RT   tuberculosis and isolation of a functional origin from M. smegmatis.";
RL   Mol. Microbiol. 20:283-293(1996).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; X92503; CAA63248.1; -; Genomic_DNA.
DR   PIR; S70986; S70986.
DR   RefSeq; WP_003898364.1; NZ_UGQO01000001.1.
DR   AlphaFoldDB; P0C557; -.
DR   SMR; P0C557; -.
DR   GeneID; 66738192; -.
DR   OMA; REFNPLF; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..504
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114217"
FT   REGION          98..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         205..212
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   504 AA;  56664 MW;  C7609F2A6D4030CB CRC64;
     MTADPDPPFV AVWNSVVAEL NGDVNGDRQG DPSLPVLTPQ QRAWLKLVKP LVIAEGFALL
     SVPTPFVQNE IERHLREPIV TALSRKLGQR VELGVRIATP TDEPEDAPDS FADSPAPASV
     PAGPADADEI DDDRDARVNA QESWPKYFSR PEPDTSSDDS NAVNLNRRYT FDTFVIGASN
     RFAHAATLAI AEAPARAYNP LFIWGESGLG KTHLLHAAGN YAQRLFPGMR VKYVSTEEFT
     NDFINSLRDD RKASFKRSYR DIDILLVDDI QFIEGKEGIQ EEFFHTFNTL HNSNKQIVIS
     SDRPPKQLAT LEDRLRTRFE WGLITDVQPP ELETRIAILR KKAQMDRLDV PDDVLELIAS
     SIERNIRELE GALIRVTAFA SLNKTRIDRS LAEVVLRDLI ADATTMQIST AAIMAVTAEY
     FETTVEELRG PGKTRALAQS RQIAMYLCRE LTDLSLPKIG QAFGRDHTTV MYAEKKIRGE
     MAERREVFDH VKELTTRIRQ RAKR