ID   DNAA_NEIMB              Reviewed;         518 AA.
AC   Q9JXS7;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=NMB1903;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; AE002098; AAF42233.1; -; Genomic_DNA.
DR   PIR; F81027; F81027.
DR   RefSeq; NP_274897.1; NC_003112.2.
DR   RefSeq; WP_002223060.1; NC_003112.2.
DR   AlphaFoldDB; Q9JXS7; -.
DR   SMR; Q9JXS7; -.
DR   STRING; 122586.NMB1903; -.
DR   PaxDb; Q9JXS7; -.
DR   EnsemblBacteria; AAF42233; AAF42233; NMB1903.
DR   GeneID; 61280603; -.
DR   KEGG; nme:NMB1903; -.
DR   PATRIC; fig|122586.8.peg.2429; -.
DR   HOGENOM; CLU_026910_0_1_4; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..518
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114221"
FT   REGION          145..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         222..229
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   518 AA;  58028 MW;  1B1BD0C49BE71E9D CRC64;
     MTLAEFWPLC LRRLHDMLPQ GQFAQWIAPL TVGEEGGVWV VYGKNQFACN MLKSQFAGKI
     EAVREELAAG RSAFVFKPGE GVRYEMAAVE GAVEPAEPSL HAVSEGMPVQ EVLLDELPSE
     EPVKPAASKT AADILAERMK NLPHEPRQAA GSASRPESVA VAKARTDVQR DAEEARYEQT
     NLSPDYTFDT LVEGKGNRLA AAAAQAIAES PGQSYNPFFL YGSTGLGKTH LVQAVGNELL
     KNRPDAKVRY MHSDDYIRSF MKAVRNNTYD VFKQQYKQYD LLIIDDIQFI KGKDRTMEEF
     FYLYNHFHNE KKQLILTCDV LPAKIEGMDD RLKSRFSWGL TLELEPPELE MRIAILQKKA
     EAAGISIEDE AALFIANLIR SNVRELEGAF NRVGASSRFM NRPVIDIDLA RTALQDIIAE
     KHKVITADII IDAVAKYYRI KISDVLGKKR TRNIARPRQV AMSLTKELTT LSLPSIGDSF
     GGRDHTTVMH GIRAVAKLRE EDPELAQDYE KLLILIQN