ID   DNAA_NOCFA              Reviewed;         662 AA.
AC   Q5Z3Z8;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=NFA_10;
OS   Nocardia farcinica (strain IFM 10152).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=247156;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152;
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
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DR   EMBL; AP006618; BAD54843.1; -; Genomic_DNA.
DR   RefSeq; WP_011206530.1; NC_006361.1.
DR   AlphaFoldDB; Q5Z3Z8; -.
DR   SMR; Q5Z3Z8; -.
DR   STRING; 247156.NFA_10; -.
DR   EnsemblBacteria; BAD54843; BAD54843; NFA_10.
DR   GeneID; 61130859; -.
DR   KEGG; nfa:NFA_10; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_2_0_11; -.
DR   OMA; RHARMTS; -.
DR   BioCyc; NFAR247156:NFA_RS00005-MON; -.
DR   Proteomes; UP000006820; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..662
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114223"
FT   REGION          96..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        261..294
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         364..371
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   662 AA;  73440 MW;  C660B701B0B8A0E3 CRC64;
     MDDEQNVLAT VWPEVIAELT TGSADGSIPA VTRAQQAWLK LVKPITVAQG FALLSVPSSL
     AQEAIERDLR EPILRSLGRR LGPQVEGLGV RIAAPATPTA ERAAANPRHA RMTSRPERPR
     GERPVPGLPG QEAVDRPETL PRYSQAAESV PGYPARQDHS RPGDYPPAAE YTPAAEYTPA
     AEYTPAAEYS PEPEYTPATD YPGADDYPTT VFRLPPGGFA EPPGDGRPGG VPEISTPRRD
     GHGPRRDATP PGQEALFTPE PGDRPLRDTD RPLREPAAGH DVRESDGPVE RDDEPVVNIR
     DSWPTYFAKN QESTPAPANS SASLNAKYTF ETFVIGASNR FAHAAAVAIA EAPARAYNPL
     FVWGASGLGK THLLHAAGHY AQRLFPGMRV KYVSTEEFTN DFINSLRDDR KVAFKRRYRE
     TDILLVDDIQ FIEGKEGIQE EFFHTFNTLH NANKQIVVSS DRPPKQLATL EERLRTRFEW
     GLITDVQPPE LETRIAILRK KARMDRLDVP HDVLELIASR VERNIRELEG ALIRVTAFAS
     LNGQPLDLSL AEVVLRDLMP DTATLEINAA TIMAVTAEYF NTTLEELTGP GKARPLAQAR
     QIAMYLCREL TDLSLPKIGQ AFGRDHTTVM YAEKKVRKEM TERRRVYDQV QELTARIKQR
     SR