ID   DNAA_PROMA              Reviewed;         461 AA.
AC   Q51896;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2003, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=Pro_0567;
OS   Prochlorococcus marinus (strain SARG / CCMP1375 / SS120).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167539;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SARG / CCMP1375 / SS120;
RX   PubMed=9563839; DOI=10.1007/s004380050679;
RA   Richter S., Hess W.R., Krause M., Messer W.;
RT   "Unique organization of the dnaA region from Prochlorococcus marinus
RT   CCMP1375, a marine cyanobacterium.";
RL   Mol. Gen. Genet. 257:534-541(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SARG / CCMP1375 / SS120;
RX   PubMed=12917486; DOI=10.1073/pnas.1733211100;
RA   Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M.,
RA   Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S.,
RA   Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J.,
RA   Tandeau de Marsac N., Weissenbach J., Wincker P., Wolf Y.I., Hess W.R.;
RT   "Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a
RT   nearly minimal oxyphototrophic genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; U44977; AAC15822.1; -; Genomic_DNA.
DR   EMBL; AE017126; AAP99612.1; -; Genomic_DNA.
DR   PIR; T52496; T52496.
DR   RefSeq; NP_874960.1; NC_005042.1.
DR   RefSeq; WP_011124720.1; NC_005042.1.
DR   AlphaFoldDB; Q51896; -.
DR   SMR; Q51896; -.
DR   STRING; 167539.Pro_0567; -.
DR   EnsemblBacteria; AAP99612; AAP99612; Pro_0567.
DR   GeneID; 54199934; -.
DR   KEGG; pma:Pro_0567; -.
DR   PATRIC; fig|167539.5.peg.582; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_3_1_3; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; 219876at2; -.
DR   Proteomes; UP000001420; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..461
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114233"
FT   REGION          85..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         162..169
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        302
FT                   /note="Q -> H (in Ref. 1; AAC15822)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   461 AA;  51403 MW;  EFDD706038D721A3 CRC64;
     MLEASWEKVQ SSLKQNLSKP SYETWIRPTE FSGFKNGELT LIAPNSFSSA WLKNNYSQTI
     QETAEEIFGE PVTVHVKVKA NAESSDEHYS SAPITPPLEA SPGSVDSSGS SLRLSKKTLP
     LLNLRYVFNR FVVGPNSRMA HAAAMAVAES PGREFNPLFI CGGVGLGKTH LMQAIGHYRL
     EIDPGAKVSY VSTETFTNDL ILAIRQDRMQ AFRDRYRAAD LILVDDIQFI EGKEYTQEEF
     FHTFNALHDA GSQIVLASDR PPSQIPRLQE RLMSRFSMGL IADVQAPDLE TRMAILQKKA
     EQERVGLPRD LIQFIAGRFT SNIRELEGAL TRAIAFASIT GLPMTVDSIA PMLDPNGQGV
     EVTPKQVLDK VAEVFKVTPD EMRSASRRRP VSQARQVGMY LMRQGTNLSL PRIGDTFGGK
     DHTTVMYAIE QVEKKLSSDP QIASQVQKIR DLLQIDSRRK R