ID   DNAA_PROMI              Reviewed;         466 AA.
AC   P22837;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA;
OS   Proteus mirabilis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=584;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LM1509;
RX   PubMed=2172087; DOI=10.1016/0378-1119(90)90131-a;
RA   Skovgaard O.;
RT   "Nucleotide sequence of a Proteus mirabilis DNA fragment homologous to the
RT   60K-rnpA-rpmH-dnaA-dnaN-recF-gyrB region of Escherichia coli.";
RL   Gene 93:27-34(1990).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; M58352; AAA83958.1; -; Genomic_DNA.
DR   PIR; JQ0733; IQEBV.
DR   RefSeq; WP_004246507.1; NZ_WEKK01000011.1.
DR   AlphaFoldDB; P22837; -.
DR   SMR; P22837; -.
DR   STRING; 584.AOUC001_18995; -.
DR   GeneID; 6801995; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; 219876at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..466
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114234"
FT   REGION          82..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..122
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         171..178
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   466 AA;  52974 MW;  F8B67C142FE9FA41 CRC64;
     MSLSLWQHCL ARLQDELPAT EFSMWIRPLQ AELSDNTLAL YAPNRFVLDW VREKYINNIN
     ALLVDFCGSD VPSLRFEVGN KPVSARTTES VPKTVTHPAV NSTPTNSQPV RPSWDNQPQS
     QLPELNYRSN VNPKHKFDNF VEGKSNQLAR AAARQVADNP GGAYNPLFLY GGTGLGKTHL
     LHAVGNSIME RKANAKVVYM HSERFVQDMV KALQNNAIED FKRYYRSVDA LLIDDIQFFA
     NKERSQEEFF HTFNALLEGN QQIILTSDRY PKEINGVEDR LKSRFGWGLT VAIEPPELET
     RVAILMKKAD ENQIQLPDEV AFFIAKRLRS NVRELEGALN RVIANANFTG RAITIDFVRE
     ALRDLLALQE KLVTIDNIQK TVAEYYKIKV ADLLSKRRSR SVARPRQMAM ALAKELTNHS
     LPEIGDAFGG RDHTTVLHAC RKIEQLREES HDIKEDFSNL IRTLSS