ID   DNAA_PROS9              Reviewed;         463 AA.
AC   P0A3A3; Q9S487;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA;
OS   Prochlorococcus marinus subsp. pastoris (strain PCC 9511).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=100363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hess W.R., Hilbig M., Holtzendorff J.;
RT   "The dnaA gene of Prochlorococcus PCC9511.";
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF158628; AAD45692.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0A3A3; -.
DR   SMR; P0A3A3; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..463
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114237"
FT   BINDING         164..171
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   463 AA;  51989 MW;  51F4138B1E659584 CRC64;
     MQAANPIWAE VQQLLQKNLS KPSFETWIRP AKFNCFENGL LTLITPNNFT SDWLRKNYSE
     TIEKAAEEIC GHNVKVVFKS ETNINNNSNS SDSVSQQNIN SQSKSFSINQ SNNLINRSKK
     SHSLNTRYVF KRFVVGPNSR MAHAAALAVA ESPGREFNPL FICGGVGLGK THLMQAVGHY
     RVEIDPDAKV LYVSTETFSS DLIQSIRKDG MHAFKNKYRS VDLLLIDDIQ FLEGKEYTQE
     EFFNTFNALY EAGKQIVIAS DRPPSQIPKL QERLISRFSM GLIADIQPPD IETRMAILQK
     KAEQERMNLP RDLIQFIAGR FSSNIRELEG AFTRAVAFAS ITGLPMTVQS IAPMLDPNSV
     GVVVTPKQVI KKVSDFFEVS AEELVSSSRR KPVSQARQIG MYLMRQGTDL SLPKIGDEFG
     GKDHTTVMYA IEQVEKKLSS DPNVASQVQK IKDLLQIDSR KNL