ID   DNAA_PSEPU              Reviewed;         506 AA.
AC   P0A117; P13454;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=TN2100;
RX   PubMed=2540413; DOI=10.1007/bf00427033;
RA   Fujita M.Q., Yoshikawa H., Ogasawara N.;
RT   "Structure of the dnaA region of Pseudomonas putida: conservation among
RT   three bacteria, Bacillus subtilis, Escherichia coli and P. putida.";
RL   Mol. Gen. Genet. 215:381-387(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26.
RX   PubMed=1588913; DOI=10.1007/bf00266248;
RA   Ingmer H., Atlung T.;
RT   "Expression and regulation of a dnaA homologue isolated from Pseudomonas
RT   putida.";
RL   Mol. Gen. Genet. 232:431-439(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-7.
RX   PubMed=2106132; DOI=10.1073/pnas.87.4.1278;
RA   Yee T.W., Smith D.W.;
RT   "Pseudomonas chromosomal replication origins: a bacterial class distinct
RT   from Escherichia coli-type origins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:1278-1282(1990).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; X14791; CAA32893.1; -; Genomic_DNA.
DR   EMBL; M30126; AAA25918.1; -; Genomic_DNA.
DR   PIR; JV0001; IQPSP.
DR   RefSeq; WP_010951427.1; NZ_SPUU01000003.1.
DR   AlphaFoldDB; P0A117; -.
DR   SMR; P0A117; -.
DR   STRING; 1240350.AMZE01000066_gene3194; -.
DR   PRIDE; P0A117; -.
DR   PATRIC; fig|303.175.peg.34; -.
DR   eggNOG; COG0593; Bacteria.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..506
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114240"
FT   REGION          135..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         211..218
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   506 AA;  56474 MW;  ABA85C094923571C CRC64;
     MSVELWQQCV ELLRDELPAQ QFNTWIRPLQ VEAEGDELRV YAPNRFVLDW VNEKYLGRLL
     ELLGENGSGI APALSLLIGS RRSSAPRAAP NAPVSAAVAA SLAQTQAHKT APAAAVEPVA
     VAAAEPVLVE TSSRDSFDAM AEPAAAPPSG GGRAEQRTVQ VEGALKHTSY LNRTFTFDTF
     VEGKSNQLAR AAAWQVADNP KHGYNPLFLY GGVGLGKTHL MHAVGNHLLK KNPNAKVVYL
     HSERFVADMV KALQLNAINE FKRFYRSVDA LLIDDIQFFA RKERSQEEFF HTFNALLEGG
     QQVILTSDRY PKEIEGLEER LKSRFGWGLT VAVEPPELET RVAILMKKAD QAKVELPHDA
     AFFIAQRIRS NVRELEGALK RVIAHSHFMG RDITIELIRE SLKDLLALQD KLVSVDNIQR
     TVAEYYKIKI SDLLSKRRSR SVARPRQVAM ALSKELTNHS LPEIGDMFGG RDHTTVLHAC
     RKINELKESD ADIREDYKNL LRTLTT