DNAA_RHIME
ID DNAA_RHIME Reviewed; 480 AA.
AC P35890;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 3.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Chromosomal replication initiator protein DnaA;
GN Name=dnaA; OrderedLocusNames=R00368; ORFNames=SMc01167;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=7751302; DOI=10.1128/jb.177.10.2892-2900.1995;
RA Margolin W., Bramhill D., Long S.R.;
RT "The dnaA gene of Rhizobium meliloti lies within an unusual gene
RT arrangement.";
RL J. Bacteriol. 177:2892-2900(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA26258.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAA91097.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAC41805.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L25439; AAA26258.1; ALT_INIT; Genomic_DNA.
DR EMBL; L39265; AAA91097.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL591688; CAC41805.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_384474.1; NC_003047.1.
DR AlphaFoldDB; P35890; -.
DR SMR; P35890; -.
DR STRING; 266834.SMc01167; -.
DR EnsemblBacteria; CAC41805; CAC41805; SMc01167.
DR KEGG; sme:SMc01167; -.
DR PATRIC; fig|266834.11.peg.1740; -.
DR eggNOG; COG0593; Bacteria.
DR HOGENOM; CLU_026910_3_0_5; -.
DR Proteomes; UP000001976; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..480
FT /note="Chromosomal replication initiator protein DnaA"
FT /id="PRO_0000114244"
FT BINDING 181..188
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 480 AA; 53580 MW; A346219949FAD6A3 CRC64;
MRHDALFERV SARLKAQVGP DVFASWFGRL KLHSVSKSVV RLSVPTTFLK SWINNRYLDL
ITTLVQQEDS EILKVEILVR TATRGHRPTA PEESVAAAAE AAVVPPSRRS AAPTVAIAAA
AVAAAPARPV QAPLFGSPLD QRYGFDSFVE GSSNRVALAA ARTIAEAGAG AVRFNPLFIH
SSVGLGKTHL LQAIALAALQ SARAPRVVYL TAEYFMWRFA TAIRDNDALS LKESLRNIDL
LIIDDMQFLQ GKSIQHEFCH LLNMLLDSAK QVVVAADRAP WELESLDSRV RSRLQGGVAI
EMEGPDYEMR LEMLKRRLEA ARQDDASLEI PLEILSHVAR NVTASGRELE GAFNQLLFRR
SFEPQLSIER VDELLGHLVN AGEPRRVRIE DIQRVVAKHY NVSRQELVSN RRTRVIVKPR
QIAMYLSKTL TPRSFPEIGR RFGGRDHTTV LHAVRKIEEL ISADTKLSHE IELLKRLINE
