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DNAA_RHIME
ID   DNAA_RHIME              Reviewed;         480 AA.
AC   P35890;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 3.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=R00368; ORFNames=SMc01167;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=7751302; DOI=10.1128/jb.177.10.2892-2900.1995;
RA   Margolin W., Bramhill D., Long S.R.;
RT   "The dnaA gene of Rhizobium meliloti lies within an unusual gene
RT   arrangement.";
RL   J. Bacteriol. 177:2892-2900(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA26258.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAA91097.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAC41805.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L25439; AAA26258.1; ALT_INIT; Genomic_DNA.
DR   EMBL; L39265; AAA91097.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL591688; CAC41805.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_384474.1; NC_003047.1.
DR   AlphaFoldDB; P35890; -.
DR   SMR; P35890; -.
DR   STRING; 266834.SMc01167; -.
DR   EnsemblBacteria; CAC41805; CAC41805; SMc01167.
DR   KEGG; sme:SMc01167; -.
DR   PATRIC; fig|266834.11.peg.1740; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_3_0_5; -.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..480
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114244"
FT   BINDING         181..188
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   480 AA;  53580 MW;  A346219949FAD6A3 CRC64;
     MRHDALFERV SARLKAQVGP DVFASWFGRL KLHSVSKSVV RLSVPTTFLK SWINNRYLDL
     ITTLVQQEDS EILKVEILVR TATRGHRPTA PEESVAAAAE AAVVPPSRRS AAPTVAIAAA
     AVAAAPARPV QAPLFGSPLD QRYGFDSFVE GSSNRVALAA ARTIAEAGAG AVRFNPLFIH
     SSVGLGKTHL LQAIALAALQ SARAPRVVYL TAEYFMWRFA TAIRDNDALS LKESLRNIDL
     LIIDDMQFLQ GKSIQHEFCH LLNMLLDSAK QVVVAADRAP WELESLDSRV RSRLQGGVAI
     EMEGPDYEMR LEMLKRRLEA ARQDDASLEI PLEILSHVAR NVTASGRELE GAFNQLLFRR
     SFEPQLSIER VDELLGHLVN AGEPRRVRIE DIQRVVAKHY NVSRQELVSN RRTRVIVKPR
     QIAMYLSKTL TPRSFPEIGR RFGGRDHTTV LHAVRKIEEL ISADTKLSHE IELLKRLINE
 
 
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