ID   DNAA_RHOOB              Reviewed;         528 AA.
AC   C1B7S7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=ROP_34830;
OS   Rhodococcus opacus (strain B4).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=632772;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B4;
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus erythropolis
RT   PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
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DR   EMBL; AP011115; BAH51730.1; -; Genomic_DNA.
DR   RefSeq; WP_012690676.1; NC_012522.1.
DR   AlphaFoldDB; C1B7S7; -.
DR   SMR; C1B7S7; -.
DR   STRING; 632772.ROP_34830; -.
DR   EnsemblBacteria; BAH51730; BAH51730; ROP_34830.
DR   KEGG; rop:ROP_34830; -.
DR   PATRIC; fig|632772.20.peg.3648; -.
DR   HOGENOM; CLU_026910_2_0_11; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; 219876at2; -.
DR   Proteomes; UP000002212; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..528
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_1000189806"
FT   REGION          93..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        96..119
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         229..236
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   528 AA;  59121 MW;  03ACB38986D9DA01 CRC64;
     MNDDPNALAR IWIDVVADLT SDSPGGDLPP LTRGQKAWLA LVKPLTLAQG FALLSVPSPF
     AQEAIERDLR EPILHALGRH LGEQVEGLGV RIAAPVDDEP ESEAPSRERR PDPEPVHTPR
     HLEPSVTSSG TFRRRRFGSG DDQPYSDTTD FEEVDDDSEA LASVHESWPS YFTKPPAGPA
     PAATGGNSLN AKYTFDTFVI GSSNRFAHAA AVAIAEAPAR AYNPLFIWGA SGLGKTHLLH
     AAGHYAQRLF PGMRVKYVST EEFTNDFINS LRDDRKVAFK RRYRETDVLL VDDIQFIEGK
     EGIQEEFFHT FNTLHNANKQ IVVSSDRPPK QLATLEERLR TRFEWGLITD VQPPELETRI
     AILSKKARMD RLEVPDDVLE LIASRIERNI RELEGALIRV TAFASLNRQP LDLTLAEVVL
     RDLMPDSSSL EINAATIMAV TAEYFNMSID DLCGPGKARP LASARQISMY LCRELTDLSL
     PKIGQTFGRD HTTVMYADKK IRKEMTERRK VYDQVQELTA RIKQRSKR