ID   DNAA_SERMA              Reviewed;         464 AA.
AC   P29440;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 3.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA;
OS   Serratia marcescens.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3040670; DOI=10.1128/jb.169.9.3976-3981.1987;
RA   Skovgaard O., Hansen F.G.;
RT   "Comparison of dnaA nucleotide sequences of Escherichia coli, Salmonella
RT   typhimurium, and Serratia marcescens.";
RL   J. Bacteriol. 169:3976-3981(1987).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. DnaA
CC       can inhibit its own gene expression as well as that of other genes.
CC   -!- SUBUNIT: Some 20 DnaA protein molecules bind their sites in oriC.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; M17353; AAA02924.1; -; Genomic_DNA.
DR   AlphaFoldDB; P29440; -.
DR   SMR; P29440; -.
DR   STRING; 273526.SMDB11_4151; -.
DR   PATRIC; fig|615.108.peg.4759; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..464
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114253"
FT   REGION          98..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         169..176
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   464 AA;  52173 MW;  8DF0AC8499E169B8 CRC64;
     MSLSLWQQCL ARLQDELPAT EFSMWIRPLQ AELSDNTLAL YAPNRFVLDW VRDKYLNNIN
     GLLNDFCGTD APLLRFEVGS KPITQVISQT VTASVSSAPA APAARTAAPS RPSWDNAAAQ
     PELSYRSNVN PKHTFDNFVE GKSNQLARAA ARQVADNPGG AYNPLFLYGG TGLGKTHLLH
     AVGNGIMARK ANAKVVYMHS ERFVQDMVKA LQNNAIEEFK RYYRSVDALL IDDIQFFANK
     ERSQEEFFHT FNALLEGNQQ IILTSDRYPK EINGVEDRLK SRFGWGLTVA IEPPELETRV
     AILMKKADEN DIRLPGEVAF FIAKRLRSNV RELEGALNRV IANANFTGRA ITIDFVREAL
     RDLLALQEKL VTIDNIQKTV AEYYKIKVAD LLSKRRSRSV ARPRQMAMAL AKELTNHSLP
     EIGDAFGGRD HTTVLHACRK IEQLREESHD IKEDFSNLIR TLSS