ID   DNAA_SPIAP              Reviewed;         263 AA.
AC   P35892;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
DE   Flags: Fragment;
GN   Name=dnaA;
OS   Spiroplasma apis.
OC   Bacteria; Tenericutes; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC   Spiroplasma.
OX   NCBI_TaxID=2137;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 33834 / B31;
RX   PubMed=8282191; DOI=10.1111/j.1574-6968.1993.tb06578.x;
RA   Suzuki K., Miyata M., Fukumura T.;
RT   "Comparison of the conserved region in the dnaA gene from three mollicute
RT   species.";
RL   FEMS Microbiol. Lett. 114:229-233(1993).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; D14986; BAA03631.1; -; Genomic_DNA.
DR   AlphaFoldDB; P35892; -.
DR   SMR; P35892; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           <1..>263
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114256"
FT   NON_TER         1
FT   NON_TER         263
SQ   SEQUENCE   263 AA;  29699 MW;  B30C4CA661154903 CRC64;
     DSGLGKTHLL KAIAHEIGNT KNKLVVKYYT SSDFRKEIVD SLQDGFKEIE STKEKLSKID
     VLLIDDIQFL ANSGKTNEIF FNLFNFFIEN NKQIVLTSDK FPEQLNGFDK RLVSRFSQGL
     NVKVETPDII TAINIVDYKA KIVNLNLSEE SKKYIASFFG SDVRKIEGII NKIEFSIIQD
     NSAAPKIIEL EDINKFLEDY SFAPGGEITV QKIKNVVAQN YGISVKSIDS RLRMANIVKA
     RHVAMFLTGE ILKKNYSEIG VAF