ID   DNAA_STRGG              Reviewed;         622 AA.
AC   B1VPF0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=SGR_3700;
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350;
RX   PubMed=18375553; DOI=10.1128/jb.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT   griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
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DR   EMBL; AP009493; BAG20529.1; -; Genomic_DNA.
DR   RefSeq; WP_012380083.1; NC_010572.1.
DR   AlphaFoldDB; B1VPF0; -.
DR   SMR; B1VPF0; -.
DR   STRING; 455632.SGR_3700; -.
DR   EnsemblBacteria; BAG20529; BAG20529; SGR_3700.
DR   GeneID; 6209512; -.
DR   KEGG; sgr:SGR_3700; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_2_0_11; -.
DR   OMA; FPERDPY; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..622
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_1000122020"
FT   REGION          88..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..133
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..206
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..237
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         323..330
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   622 AA;  69567 MW;  6C70D29EF4AB66C6 CRC64;
     MADVPADLAA VWPRVLEQLL GEGQQGIEPK DKQWIERCQP LALVADTALL AVPNEWGKRV
     LEGRLAPLIS ETLTRECGRP IRIAITVDDS AGEPPAPPAP PMHQSHQGPQ GHRYPSQQRD
     DAPRGDTYDG YGHRPSDDGM PTARPAYPDY QQQRPEPGAW PRTQEDLSWQ QPRHGGYQDR
     EQPPGEPYRE SEAYQRESEQ YREQPPEPWR EPYGAGRPQQ HDYRSQPPEH QGYEQQRPDR
     QDQQQPGPRP GGHGPGRTGG SVPGPMGAQP SPAPGPGEPH ARLNPKYLFD TFVIGASNRF
     AHAAAVAVAE APAKAYNPLF IYGESGLGKT HLLHAIGHYA RSLYPGTRVR YVSSEEFTNE
     FINSIRDGKG DTFRKRYRDV DILLVDDIQF LASKESTQEE FFHTFNTLHN ANKQIVLSSD
     RPPKQLVTLE DRLRNRFEWG LTTDVQPPEL ETRIAILRKK AVQEQLNAPP EVLEFIASRI
     SRNIRELEGA LIRVTAFASL NRQPVDLGLT EIVLKDLIPG GEESAPEITA PAIMAATADY
     FGLTVDDLCG SSRSRVLVTA RQIAMYLCRE LTDLSLPKIG AQFGGRDHTT VMHADRKIRA
     LMAERRSIYN QVTELTNRIK NG