ID   DNAA_STRP1              Reviewed;         451 AA.
AC   P0A3A4; Q491U8; Q9L572;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=SPy_0002, M5005_Spy0001;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=10930754; DOI=10.1111/j.1574-6968.2000.tb09246.x;
RA   Suvorov A.N., Ferretti J.J.;
RT   "Replication origin of Streptococcus pyogenes, organization and cloning in
RT   heterologous systems.";
RL   FEMS Microbiol. Lett. 189:293-297(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; AF255728; AAF71535.1; -; Genomic_DNA.
DR   EMBL; AE004092; AAK33146.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ50620.1; -; Genomic_DNA.
DR   RefSeq; NP_268424.1; NC_002737.2.
DR   AlphaFoldDB; P0A3A4; -.
DR   SMR; P0A3A4; -.
DR   STRING; 1314.HKU360_00001; -.
DR   PaxDb; P0A3A4; -.
DR   EnsemblBacteria; AAK33146; AAK33146; SPy_0002.
DR   GeneID; 57851817; -.
DR   KEGG; spy:SPy_0002; -.
DR   KEGG; spz:M5005_Spy0001; -.
DR   PATRIC; fig|160490.10.peg.1; -.
DR   HOGENOM; CLU_026910_3_2_9; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..451
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114275"
FT   BINDING         152..159
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   451 AA;  51665 MW;  F206238154A9A33E CRC64;
     MTENEQIFWN RVLELAQSQL KQATYEFFVH DARLLKVDKH IATIYLDQMK ELFWEKNLKD
     VILTAGFEVY NAQISVDYVF EEDLMIEQNQ TKINQKPKQQ ALNSLPTVTS DLNSKYSFEN
     FIQGDENRWA VAASIAVANT PGTTYNPLFI WGGPGLGKTH LLNAIGNSVL LENPNARIKY
     ITAENFINEF VIHIRLDTMD ELKEKFRNLD LLLIDDIQSL AKKTLSGTQE EFFNTFNALH
     NNNKQIVLTS DRTPDHLNDL EDRLVTRFKW GLTVNITPPD FETRVAILTN KIQEYNFIFP
     QDTIEYLAGQ FDSNVRDLEG ALKDISLVAN FKQIDTITVD IAAEAIRARK QDGPKMTVIP
     IEEIQAQVGK FYGVTVKEIK ATKRTQNIVL ARQVAMFLAR EMTDNSLPKI GKEFGGRDHS
     TVLHAYNKIK NMISQDESLR IEIETIKNKI K