ID   DNAA_STRPN              Reviewed;         453 AA.
AC   O08397;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2001, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=SP_0001;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=R801;
RA   Gasc A.A.;
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; AF000658; AAC45336.1; -; Genomic_DNA.
DR   EMBL; AE005672; AAK74194.1; -; Genomic_DNA.
DR   PIR; A95000; A95000.
DR   RefSeq; WP_000660618.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; O08397; -.
DR   SMR; O08397; -.
DR   STRING; 170187.SP_0001; -.
DR   EnsemblBacteria; AAK74194; AAK74194; SP_0001.
DR   KEGG; spn:SP_0001; -.
DR   eggNOG; COG0593; Bacteria.
DR   OMA; REFNPLF; -.
DR   PhylomeDB; O08397; -.
DR   BioCyc; SPNE170187:G1FZB-1-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..453
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114273"
FT   BINDING         155..162
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        90
FT                   /note="V -> G (in Ref. 1; AAC45336)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        100
FT                   /note="N -> D (in Ref. 1; AAC45336)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   453 AA;  51781 MW;  D94D314FB7E9D471 CRC64;
     MKEKQFWNRI LEFAQERLTR SMYDFYAIQA ELIKVEENVA TIFLPRSEME MVWEKQLKDI
     IVVAGFEIYD AEITPHYIFT KPQDTTSSQV EEATNLTLYN YSPKLVSIPY SDTGLKEKYT
     FDNFIQGDGN VWAVSAALAV SEDLALTYNP LFIYGGPGLG KTHLLNAIGN EILKNIPNAR
     VKYIPAESFI NDFLDHLRLG EMEKFKKTYR SLDLLLIDDI QSLSGKKVAT QEEFFNTFNA
     LHDKQKQIVL TSDRSPKHLE GLEERLVTRF SWGLTQTITP PDFETRIAIL QSKTEHLGYN
     FQSDTLEYLA GQFDSNVRDL EGAINDITLI ARVKKIKDIT IDIAAEAIRA RKQDVSQMLV
     IPIDKIQTEV GNFYGVSIKE MKGSRRLQNI VLARQVAMYL SRELTDNSLP KIGKEFGGKD
     HTTVIHAHAK IKSLIDQDDN LRLEIESIKK KIK