ID   DNAA_STRRE              Reviewed;         643 AA.
AC   Q9ZH76;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA;
OS   Streptomyces reticuli.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Tu45;
RX   PubMed=10095766; DOI=10.1046/j.1432-1327.1999.00168.x;
RA   Majka J., Jakimowicz D., Messer W., Schrempf H., Lisowski M.,
RA   Zakrzewska-Czerwinska J.;
RT   "Interactions of the Streptomyces lividans initiator protein DnaA with its
RT   target.";
RL   Eur. J. Biochem. 260:325-335(1999).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; AF071023; AAD08806.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9ZH76; -.
DR   SMR; Q9ZH76; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..643
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114279"
FT   REGION          87..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..268
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..294
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         344..351
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   643 AA;  71318 MW;  DB9E173DF24758B5 CRC64;
     MADVPADLAA VWPRVLEQLL GEGRGQGVEA KDEHWIRRCQ PLALVADTAL LAVPNEFAKG
     VLEGRLAPIV SETLSRECGR PIRIAITVDD SAGEPPPAAP PAQQTPKPRY EEPELPSGPY
     EGYGRHRGGA DQLPGTEPRP EQLPSARPDQ LPTVRPAYPS EYHRPEPGAW PRPAQDEYGW
     QQPRLGFPER DPYASPSSQD AYGSPSQDYR PQGMDRPPYE QQRGDYDTPR AEYEPARPDY
     DSARPDYESA RPEYDQRDPV RRELPEPPAH RGGPGADMPS AGAPGPPAAQ PAPASGPGEP
     TARLNPKYLF DTFVIGASNR FAHAAAVAVA EAPAKAYNPL FIYGESGLGK THLLHAIGHY
     ARSLYPGTRV RYVSSEEFTN EFINSIRDGK GDSFRKRYRE MDILLVDDIQ FLADKESTQE
     EFFHTFNTLH NANKQIVLSS DRPPKQLVTL EDRLRNRFEW GLITDVQPPE LETRIAILRK
     KAVQEQLNAP PEVLEFIASR ISRNIRELEG ALIRVTAFAS LNRQPVDLGL TEIVLKDLIP
     GGEDSTPEIT ATAIMAATAD YFGLTVDDLC GSSRGRQLVT ARQIAMYLCR ELTDLSLPKI
     GAQFGGRDHT TVMHADRKIR ALMAERRSIY NQVTELTNRI KNG