ID   DNAA_SYNY3              Reviewed;         447 AA.
AC   P49995; P73750;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=sll0848;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7635812; DOI=10.1128/jb.177.15.4245-4251.1995;
RA   Richter S., Messer W.;
RT   "Genetic structure of the dnaA region of the cyanobacterium Synechocystis
RT   sp. strain PCC6803.";
RL   J. Bacteriol. 177:4245-4251(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; L36958; AAA85913.1; -; Genomic_DNA.
DR   EMBL; BA000022; BAA17801.1; -; Genomic_DNA.
DR   PIR; S74840; S74840.
DR   AlphaFoldDB; P49995; -.
DR   SMR; P49995; -.
DR   IntAct; P49995; 2.
DR   STRING; 1148.1652883; -.
DR   PaxDb; P49995; -.
DR   EnsemblBacteria; BAA17801; BAA17801; BAA17801.
DR   KEGG; syn:sll0848; -.
DR   eggNOG; COG0593; Bacteria.
DR   InParanoid; P49995; -.
DR   OMA; REFNPLF; -.
DR   PhylomeDB; P49995; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..447
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114285"
FT   BINDING         147..154
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        118..125
FT                   /note="VGPTNRMA -> WAHQSHG (in Ref. 1; AAA85913)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        297
FT                   /note="I -> M (in Ref. 1; AAA85913)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   447 AA;  50050 MW;  8ACA68D6CC38D3BF CRC64;
     MVSCENLWQQ ALAILATQLT KPAFDTWIKA SVLISLGDGV ATIQVENGFV LNHLQKSYGP
     LLMEVLTDLT GQEITVKLIT DGLEPHSLIG QESSLPMETT PKNATALNGK YTFSRFVVGP
     TNRMAHAASL AVAESPGREF NPLFLCGGVG LGKTHLMQAI AHYRLEMYPN AKVYYVSTER
     FTNDLITAIR QDNMEDFRSY YRSADFLLID DIQFIKGKEY TQEEFFHTFN SLHEAGKQVV
     VASDRAPQRI PGLQDRLISR FSMGLIADIQ VPDLETRMAI LQKKAEYDRI RLPKEVIEYI
     ASHYTSNIRE LEGALIRAIA YTSLSNVAMT VENIAPVLNP PVEKVAAAPE TIITIVAQHY
     QLKVEELLSN SRRREVSLAR QVGMYLMRQH TDLSLPRIGE AFGGKDHTTV MYSCDKITQL
     QQKDWETSQT LTSLSHRINI AGQAPES