DNAA_THEMA
ID DNAA_THEMA Reviewed; 440 AA.
AC P46798;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Chromosomal replication initiator protein DnaA;
GN Name=dnaA; OrderedLocusNames=TM_0926;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=8168477; DOI=10.1002/j.1460-2075.1994.tb06445.x;
RA Darimont B., Sterner R.;
RT "Sequence, assembly and evolution of a primordial ferredoxin from
RT Thermotoga maritima.";
RL EMBO J. 13:1772-1781(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U24145; AAA65438.1; -; Genomic_DNA.
DR EMBL; AE000512; AAD36007.1; -; Genomic_DNA.
DR PIR; G72317; G72317.
DR RefSeq; NP_228734.1; NC_000853.1.
DR RefSeq; WP_004080636.1; NZ_CP011107.1.
DR PDB; 2Z4R; X-ray; 3.05 A; A/B/C=1-440.
DR PDB; 2Z4S; X-ray; 3.00 A; A=1-440.
DR PDBsum; 2Z4R; -.
DR PDBsum; 2Z4S; -.
DR AlphaFoldDB; P46798; -.
DR SMR; P46798; -.
DR STRING; 243274.THEMA_00005; -.
DR EnsemblBacteria; AAD36007; AAD36007; TM_0926.
DR KEGG; tma:TM0926; -.
DR eggNOG; COG0593; Bacteria.
DR InParanoid; P46798; -.
DR OMA; REFNPLF; -.
DR OrthoDB; 219876at2; -.
DR EvolutionaryTrace; P46798; -.
DR PRO; PR:P46798; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0006260; P:DNA replication; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Cytoplasm; DNA replication; DNA-binding;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..440
FT /note="Chromosomal replication initiator protein DnaA"
FT /id="PRO_0000114286"
FT BINDING 137..144
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT HELIX 104..106
FT /evidence="ECO:0007829|PDB:2Z4S"
FT TURN 111..113
FT /evidence="ECO:0007829|PDB:2Z4S"
FT HELIX 114..125
FT /evidence="ECO:0007829|PDB:2Z4S"
FT TURN 127..129
FT /evidence="ECO:0007829|PDB:2Z4R"
FT STRAND 133..136
FT /evidence="ECO:0007829|PDB:2Z4S"
FT STRAND 138..142
FT /evidence="ECO:0007829|PDB:2Z4S"
FT HELIX 143..157
FT /evidence="ECO:0007829|PDB:2Z4S"
FT STRAND 158..161
FT /evidence="ECO:0007829|PDB:2Z4R"
FT STRAND 163..167
FT /evidence="ECO:0007829|PDB:2Z4S"
FT HELIX 168..180
FT /evidence="ECO:0007829|PDB:2Z4S"
FT HELIX 184..191
FT /evidence="ECO:0007829|PDB:2Z4S"
FT TURN 192..194
FT /evidence="ECO:0007829|PDB:2Z4S"
FT STRAND 196..201
FT /evidence="ECO:0007829|PDB:2Z4S"
FT HELIX 203..206
FT /evidence="ECO:0007829|PDB:2Z4S"
FT HELIX 210..224
FT /evidence="ECO:0007829|PDB:2Z4S"
FT TURN 225..227
FT /evidence="ECO:0007829|PDB:2Z4S"
FT STRAND 229..236
FT /evidence="ECO:0007829|PDB:2Z4S"
FT HELIX 238..240
FT /evidence="ECO:0007829|PDB:2Z4S"
FT HELIX 246..253
FT /evidence="ECO:0007829|PDB:2Z4S"
FT STRAND 254..256
FT /evidence="ECO:0007829|PDB:2Z4S"
FT HELIX 265..279
FT /evidence="ECO:0007829|PDB:2Z4S"
FT HELIX 287..294
FT /evidence="ECO:0007829|PDB:2Z4S"
FT HELIX 299..315
FT /evidence="ECO:0007829|PDB:2Z4S"
FT STRAND 316..318
FT /evidence="ECO:0007829|PDB:2Z4S"
FT HELIX 322..328
FT /evidence="ECO:0007829|PDB:2Z4S"
FT TURN 331..333
FT /evidence="ECO:0007829|PDB:2Z4S"
SQ SEQUENCE 440 AA; 50304 MW; 2E35ED82650A5C2E CRC64;
MKERILQEIK TRVNRKSWEL WFSSFDVKSI EGNKVVFSVG NLFIKEWLEK KYYSVLSKAV
KVVLGNDATF EITYEAFEPH SSYSEPLVKK RAVLLTPLNP DYTFENFVVG PGNSFAYHAA
LEVAKHPGRY NPLFIYGGVG LGKTHLLQSI GNYVVQNEPD LRVMYITSEK FLNDLVDSMK
EGKLNEFREK YRKKVDILLI DDVQFLIGKT GVQTELFHTF NELHDSGKQI VICSDREPQK
LSEFQDRLVS RFQMGLVAKL EPPDEETRKS IARKMLEIEH GELPEEVLNF VAENVDDNLR
RLRGAIIKLL VYKETTGKEV DLKEAILLLK DFIKPNRVKA MDPIDELIEI VAKVTGVPRE
EILSNSRNVK ALTARRIGMY VAKNYLKSSL RTIAEKFNRS HPVVVDSVKK VKDSLLKGNK
QLKALIDEVI GEISRRALSG
