ID   DNAA_THET8              Reviewed;         436 AA.
AC   Q9X9D5; Q5SGV7;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=TTHA1973;
OS   Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=300852;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RX   PubMed=10835275; DOI=10.1006/jmbi.2000.3764;
RA   Schaper S., Nardmann J., Lueder G., Lurz R., Speck C., Messer W.;
RT   "Identification of the chromosomal replication origin from Thermus
RT   thermophilus and its interaction with the replication initiator DnaA.";
RL   J. Mol. Biol. 299:655-665(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27634 / DSM 579 / HB8;
RA   Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA   Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT   "Complete genome sequence of Thermus thermophilus HB8.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC   -!- SUBUNIT: Some 16-18 DnaA protein molecules bind their sites in oriC.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; AJ133785; CAB40110.1; -; Genomic_DNA.
DR   EMBL; AP008226; BAD71796.1; -; Genomic_DNA.
DR   RefSeq; WP_011229057.1; NC_006461.1.
DR   RefSeq; YP_145239.1; NC_006461.1.
DR   AlphaFoldDB; Q9X9D5; -.
DR   SMR; Q9X9D5; -.
DR   STRING; 300852.55773355; -.
DR   EnsemblBacteria; BAD71796; BAD71796; BAD71796.
DR   GeneID; 3169856; -.
DR   KEGG; ttj:TTHA1973; -.
DR   PATRIC; fig|300852.9.peg.1944; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_3_1_0; -.
DR   OMA; REFNPLF; -.
DR   PhylomeDB; Q9X9D5; -.
DR   Proteomes; UP000000532; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..436
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114288"
FT   BINDING         142..149
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   436 AA;  49388 MW;  9367A92F700F6234 CRC64;
     MSHEAVWQHV LEHIRRSITE VEFHTWFERI RPLGIRDGVL ELAVPTSFAL DWIRRHYAGL
     IQEALGLLGA QAPRFELRVV PGVVVQEDIF QAAPAEAPRP KLNPKYTFEN FVVGPNNSMA
     HAAAVAVAES PGRAYNPLFI YGGVGLGKTH LMHAVGHSVA KRFPHLRIEY VSTETFTNEL
     INAIREDRMT EFRERYRSVD LLLVDDVQFI AGKERTQEEF FHTFNALYEA HKQIILSSDR
     PPKDILTLEA RLRSRFEWGL ITDIQPPDLE TRIAILKMNA EQRGLRIPED ALEYIARQVT
     SNIRELEGAL MRAIAFASLN GVELTRAVAA KALSDIFAPR ELEADPLEII RKVADHFGLK
     PEELTGSGRK KEVVLPRQLA MYLVRELTRA SLPEIGQLFG GRDHTTVLYA IQKVQELAES
     DREVQGLLRT LREACT