ID   DNAA_UREPA              Reviewed;         457 AA.
AC   Q9PRE2;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=UU001;
OS   Ureaplasma parvum serovar 3 (strain ATCC 700970).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=273119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700970;
RX   PubMed=11048724; DOI=10.1038/35037619;
RA   Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y.,
RA   Cassell G.H.;
RT   "The complete sequence of the mucosal pathogen Ureaplasma urealyticum.";
RL   Nature 407:757-762(2000).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; AF222894; AAF30408.1; -; Genomic_DNA.
DR   RefSeq; WP_006688755.1; NC_002162.1.
DR   AlphaFoldDB; Q9PRE2; -.
DR   SMR; Q9PRE2; -.
DR   STRING; 273119.UU001; -.
DR   EnsemblBacteria; AAF30408; AAF30408; UU001.
DR   GeneID; 29672652; -.
DR   KEGG; uur:UU001; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_3_2_14; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000000423; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..457
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114294"
FT   BINDING         153..160
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   457 AA;  52655 MW;  3F5AE8C5927F0BE2 CRC64;
     MANNYQTLYD SAIKRIPYDL ISDQAYAILQ NAKTHKVCDG VLYIIVANAF EKSIINGNFI
     NIISKYLSEE FKKENIVNFE FIIDNEKLLI NSNFLIKETN IKNRFNFSDE LLRYNFNNLV
     ISNFNQKAIK AIENLFSNNY DNSSMCNPLF LFGKVGVGKT HIVAAAGNRF ANSNPNLKIY
     YYEGQDFFRK FCSASLKGTS YVEEFKKEIA SADLLIFEDI QNIQSRDSTA ELFFNIFNDI
     KLNGGKIILT SDRTPNELNG FHNRIISRLA SGLQCKISQP DKNEAIKIIN NWFEFKKKYQ
     ITDEAKEYIA EGFHTDIRQM IGNLKQICFW ADNDTNKDLI ITKDYVIECS VENEIPLNIV
     VKKQFKPEQI IEIVAKELNI KTDLIKSSIR KNNIVWARDI VCYILKNKLN LTLTDIGKLL
     NGREHTTISH SISKVQKILD DENSQEALQI NLIINKF