DNAA_VIBHA
ID DNAA_VIBHA Reviewed; 468 AA.
AC P49996;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Chromosomal replication initiator protein DnaA;
GN Name=dnaA;
OS Vibrio harveyi (Beneckea harveyi).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=669;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=ATCC 33843 / NCIMB 1871 / 392 / MAV;
RX PubMed=11948168; DOI=10.1128/jb.184.9.2533-2538.2002;
RA Berenstein D., Olesen K., Speck C., Skovgaard O.;
RT "Genetic organization of the Vibrio harveyi dnaA gene region and analysis
RT of the function of the V. harveyi DnaA protein in Escherichia coli.";
RL J. Bacteriol. 184:2533-2538(2002).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. DnaA
CC can inhibit its own gene expression. {ECO:0000269|PubMed:11948168}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L47617; AAA78257.1; -; Genomic_DNA.
DR RefSeq; WP_005451061.1; NZ_QOWF01000010.1.
DR AlphaFoldDB; P49996; -.
DR SMR; P49996; -.
DR STRING; 669.AL538_09690; -.
DR GeneID; 57819734; -.
DR OrthoDB; 219876at2; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT CHAIN 1..468
FT /note="Chromosomal replication initiator protein DnaA"
FT /id="PRO_0000114297"
FT REGION 85..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 173..180
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 468 AA; 53077 MW; 1C6A373345A8C051 CRC64;
MSSSLWLQCL QQLQEELPAT EFSMWVRPLQ AELNDNTLTL FAPNRFVLDW VRDKYLNSIN
RLLQEYCGND VPSLRFEVGS RRVAAPKPAP TRTPADVAAE SSAPAQLQAR KPVHKTWDDD
AQVIADINHR SNVNPKHKFN NFVEGKSNQL GLAAARQVSD NPGAAYNPLF LYGGTGLGKT
HLLHAVGNAI VDNNPNAKVV YMHSERFVQD MVKALQNNAI EEFKRYYRSV DALLIDDIQF
FANKERSQEE FFHTFNALLE GNQQIILTSD RYPKEISGVE DRLKSRFGWG LTVAIEPPEL
ETRVAILMKK AEDHQIHLAD EVAFFIAKRL RSNVRELEGA LNRVIANANF TGRPITIDFV
REALRDLLAL QEKLVTIDNI QKTVAEYYKI KVADLLSKRR SRSVARPRQL AMALAKELTN
HSLPEIGDAF GGRDHTTVLH ACRKIEQLRE ESHDIKEDYS NLIRTLSS