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DNAB_HELPY
ID   DNAB_HELPY              Reviewed;         488 AA.
AC   O25916;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Replicative DNA helicase;
DE            EC=3.6.4.12;
GN   Name=dnaB; OrderedLocusNames=HP_1362;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Participates in initiation and elongation during chromosome
CC       replication; it exhibits DNA-dependent ATPase activity and contains
CC       distinct active sites for ATP binding, DNA binding, and interaction
CC       with DnaC protein, primase, and other prepriming proteins.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- INTERACTION:
CC       O25916; O25916: dnaB; NbExp=6; IntAct=EBI-7529552, EBI-7529552;
CC   -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000511; AAD08402.1; -; Genomic_DNA.
DR   PIR; B64690; B64690.
DR   RefSeq; NP_208154.1; NC_000915.1.
DR   RefSeq; WP_000349722.1; NC_018939.1.
DR   PDB; 3GXV; X-ray; 2.20 A; A/B=1-121, C=101-122, D=98-123.
DR   PDB; 4A1F; X-ray; 2.50 A; A/B=152-488.
DR   PDB; 4ZC0; X-ray; 6.70 A; A/B/C/D=1-488.
DR   PDBsum; 3GXV; -.
DR   PDBsum; 4A1F; -.
DR   PDBsum; 4ZC0; -.
DR   AlphaFoldDB; O25916; -.
DR   SMR; O25916; -.
DR   DIP; DIP-3388N; -.
DR   IntAct; O25916; 4.
DR   MINT; O25916; -.
DR   STRING; 85962.C694_07030; -.
DR   PaxDb; O25916; -.
DR   EnsemblBacteria; AAD08402; AAD08402; HP_1362.
DR   KEGG; hpy:HP_1362; -.
DR   PATRIC; fig|85962.47.peg.1459; -.
DR   eggNOG; COG0305; Bacteria.
DR   OMA; WENLAKC; -.
DR   PhylomeDB; O25916; -.
DR   EvolutionaryTrace; O25916; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IBA:GO_Central.
DR   CDD; cd00984; DnaB_C; 1.
DR   Gene3D; 1.10.860.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR   InterPro; IPR007692; DNA_helicase_DnaB.
DR   InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR   InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR   InterPro; IPR016136; DNA_helicase_N/primase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00772; DnaB; 1.
DR   Pfam; PF03796; DnaB_C; 1.
DR   SUPFAM; SSF48024; SSF48024; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00665; DnaB; 1.
DR   PROSITE; PS51199; SF4_HELICASE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; DNA replication; DNA-binding; Helicase;
KW   Hydrolase; Nucleotide-binding; Primosome; Reference proteome.
FT   CHAIN           1..488
FT                   /note="Replicative DNA helicase"
FT                   /id="PRO_0000102023"
FT   DOMAIN          172..471
FT                   /note="SF4 helicase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00596"
FT   BINDING         203..210
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00596"
FT   HELIX           3..23
FT                   /evidence="ECO:0007829|PDB:3GXV"
FT   HELIX           25..27
FT                   /evidence="ECO:0007829|PDB:3GXV"
FT   HELIX           28..32
FT                   /evidence="ECO:0007829|PDB:3GXV"
FT   HELIX           37..39
FT                   /evidence="ECO:0007829|PDB:3GXV"
FT   HELIX           43..57
FT                   /evidence="ECO:0007829|PDB:3GXV"
FT   HELIX           64..69
FT                   /evidence="ECO:0007829|PDB:3GXV"
FT   STRAND          73..75
FT                   /evidence="ECO:0007829|PDB:3GXV"
FT   HELIX           79..86
FT                   /evidence="ECO:0007829|PDB:3GXV"
FT   HELIX           95..120
FT                   /evidence="ECO:0007829|PDB:3GXV"
FT   HELIX           154..171
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   TURN            172..174
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   HELIX           184..190
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   STRAND          198..203
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   HELIX           209..222
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   STRAND          226..234
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   HELIX           236..248
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   HELIX           252..257
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   HELIX           262..277
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   STRAND          280..283
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   HELIX           290..303
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   STRAND          307..316
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   HELIX           321..326
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   HELIX           331..345
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   STRAND          349..354
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   HELIX           357..361
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   STRAND          362..364
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   HELIX           369..371
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   STRAND          372..374
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   STRAND          383..389
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   HELIX           391..407
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   HELIX           408..410
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   HELIX           412..431
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   STRAND          434..445
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   STRAND          451..458
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   HELIX           459..461
FT                   /evidence="ECO:0007829|PDB:4A1F"
FT   TURN            469..471
FT                   /evidence="ECO:0007829|PDB:4A1F"
SQ   SEQUENCE   488 AA;  55726 MW;  6FF84C2DE4ED606F CRC64;
     MDHLKHLQQL QNIERIVLSG IVLANHKIEE VHSVLEPSDF YYPPNGLFFE IALKLHEEDC
     PIDENFIRQK MPKDKQIKEE DLVAIFAASP IDNIEAYVEE IKNASIKRKL FGLANTIREQ
     ALESAQKSSD ILGAVEREVY ALLNGSTIEG FRNIKEVLES AMDLITENQR KGSLEVTGIP
     TGFVQLDNYT SGFNKGSLVI IGARPSMGKT SLMMNMVLSA LNDDRGVAVF SLEMSAEQLA
     LRALSDLTSI NMHDLESGRL DDDQWENLAK CFDHLSQKKL FFYDKSYVRI EQIRLQLRKL
     KSQHKELGIA FIDYLQLMSG SKATKERHEQ IAEISRELKT LARELEIPII ALVQLNRSLE
     NRDDKRPILS DIKDSGGIEQ DADIVLFLYR GYIYQMRAED NKIDKLKKEG KIEEAQELYL
     KVNEERRIHK QNGSIEEAEI IVAKNRNGAT GTVYTRFNAP FTRYEDMPID SHLEEGQETK
     VDYDIVTT
 
 
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