DNAB_MYCPN
ID DNAB_MYCPN Reviewed; 473 AA.
AC P75539;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Replicative DNA helicase;
DE EC=3.6.4.12;
GN Name=dnaB; OrderedLocusNames=MPN_232; ORFNames=MP599;
OS Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS pneumoniae).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=272634;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29342 / M129;
RX PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT pneumoniae.";
RL Nucleic Acids Res. 24:4420-4449(1996).
CC -!- FUNCTION: Participates in initiation and elongation during chromosome
CC replication; it exhibits DNA-dependent ATPase activity. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
CC {ECO:0000305}.
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DR EMBL; U00089; AAB96247.1; -; Genomic_DNA.
DR PIR; S73925; S73925.
DR RefSeq; NP_109920.1; NC_000912.1.
DR RefSeq; WP_010874589.1; NC_000912.1.
DR AlphaFoldDB; P75539; -.
DR SMR; P75539; -.
DR IntAct; P75539; 2.
DR STRING; 272634.MPN_232; -.
DR EnsemblBacteria; AAB96247; AAB96247; MPN_232.
DR KEGG; mpn:MPN_232; -.
DR PATRIC; fig|272634.6.peg.251; -.
DR HOGENOM; CLU_005373_0_0_14; -.
DR OMA; IEFHARI; -.
DR BioCyc; MPNE272634:G1GJ3-370-MON; -.
DR Proteomes; UP000000808; Chromosome.
DR GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW.
DR CDD; cd00984; DnaB_C; 1.
DR Gene3D; 1.10.860.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR016136; DNA_helicase_N/primase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF03796; DnaB_C; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51199; SF4_HELICASE; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; DNA-binding; Helicase; Hydrolase;
KW Nucleotide-binding; Primosome; Reference proteome.
FT CHAIN 1..473
FT /note="Replicative DNA helicase"
FT /id="PRO_0000102026"
FT DOMAIN 191..469
FT /note="SF4 helicase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00596"
FT BINDING 222..229
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00596"
SQ SEQUENCE 473 AA; 54490 MW; 2E265A35D972C872 CRC64;
MVSNKLEQTF KFANDKNIER AERVLMQALV QDAVGVDLIL TKLEPKDFFG FPFNFIFQTA
QENYSEGNKL FGSALLEAVK FKLDTDSKTQ REIEGLFEDV LLKGLPFLER DIKVFVDVVK
KASIFRQLKQ FAKKVEKEEF KVKDDRFEGY LQAIQNDFTK IIHSAFVSIP GLSYDEIVRE
EEELIPKVYR GELTVKGLKS GFYPLDQLTS GWKEGELIVV AARPGRGKTA LLINFLQGAV
NDSEKFDKNK DVLLFFSLEM RNREIYQRHL MLESQVNYTL TSRQRLANVY DDLIKASEVL
RDLPIKIFDY STITLDEIRA QITEVSKTNN VKLVVIDYLQ LVNAFKNSYN ISRQQEVTMI
SKSLKSFAKE FNVPIIAAAQ LSRRIEERKD SRPILSDLRE SGSIEQDADM VLFIHRVKDE
DSENQEAIGH NNIFQVELIL EKNRSGPTGK VQFDFQSDVS TFRVREYNPD GYS
