ID   DNAC_ECO57              Reviewed;         245 AA.
AC   P0AEF2; P07905;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=DNA replication protein DnaC;
GN   Name=dnaC; OrderedLocusNames=Z5961, ECs5321;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: This protein is required for chromosomal replication. It
CC       forms, in concert with DnaB protein and other prepriming proteins DnaT,
CC       N, N', N'' a prepriming protein complex on the specific site of the
CC       template DNA recognized by protein N' (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaC family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG59544.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB38744.1; -; Genomic_DNA.
DR   PIR; A91294; A91294.
DR   PIR; D86135; D86135.
DR   RefSeq; NP_313348.1; NC_002695.1.
DR   RefSeq; WP_000799911.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AEF2; -.
DR   SMR; P0AEF2; -.
DR   STRING; 155864.EDL933_5704; -.
DR   EnsemblBacteria; AAG59544; AAG59544; Z5961.
DR   EnsemblBacteria; BAB38744; BAB38744; ECs_5321.
DR   GeneID; 66671753; -.
DR   GeneID; 913577; -.
DR   KEGG; ece:Z5961; -.
DR   KEGG; ecs:ECs_5321; -.
DR   PATRIC; fig|386585.9.peg.5565; -.
DR   eggNOG; COG1484; Bacteria.
DR   HOGENOM; CLU_062999_3_1_6; -.
DR   OMA; VGDLMKR; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR028350; DNAC/ATP-binding.
DR   InterPro; IPR002611; IstB_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01695; IstB_IS21; 1.
DR   PIRSF; PIRSF003073; DNAC_TnpB_IstB; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Primosome;
KW   Reference proteome.
FT   CHAIN           1..245
FT                   /note="DNA replication protein DnaC"
FT                   /id="PRO_0000079955"
FT   SITE            69
FT                   /note="Probably involved in the interaction with the DnaB
FT                   protein"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   245 AA;  27935 MW;  C5CC7232E21F11F1 CRC64;
     MKNVGDLMQR LQKMMPAHIK PAFKTGEELL AWQKEQGAIR SAALERENRA MKMQRTFNRS
     GIRPLHQNCS FENYRVECEG QMNALSKARQ YVEEFDGNIA SFIFSGKPGT GKNHLAAAIC
     NELLLRGKSV LIITVADIMS AMKDTFRNSG TSEEQLLNDL SNVDLLVIDE IGVQTESKYE
     KVIINQIVDR RSSSKRPTGM LTNSNMEEMT KLLGERVMDR MRLGNSLWVI FNWDSYRSRV
     TGKEY