ID   DNAC_ECOL6              Reviewed;         245 AA.
AC   P0AEF1; P07905;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA replication protein DnaC;
GN   Name=dnaC; OrderedLocusNames=c5440;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: This protein is required for chromosomal replication. It
CC       forms, in concert with DnaB protein and other prepriming proteins DnaT,
CC       N, N', N'' a prepriming protein complex on the specific site of the
CC       template DNA recognized by protein N' (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaC family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN83860.1; -; Genomic_DNA.
DR   RefSeq; WP_000799911.1; NC_004431.1.
DR   AlphaFoldDB; P0AEF1; -.
DR   SMR; P0AEF1; -.
DR   STRING; 199310.c5440; -.
DR   EnsemblBacteria; AAN83860; AAN83860; c5440.
DR   GeneID; 66671753; -.
DR   KEGG; ecc:c5440; -.
DR   eggNOG; COG1484; Bacteria.
DR   HOGENOM; CLU_062999_3_1_6; -.
DR   OMA; VGDLMKR; -.
DR   BioCyc; ECOL199310:C5440-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR028350; DNAC/ATP-binding.
DR   InterPro; IPR002611; IstB_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01695; IstB_IS21; 1.
DR   PIRSF; PIRSF003073; DNAC_TnpB_IstB; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Primosome.
FT   CHAIN           1..245
FT                   /note="DNA replication protein DnaC"
FT                   /id="PRO_0000079956"
FT   SITE            69
FT                   /note="Probably involved in the interaction with the DnaB
FT                   protein"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   245 AA;  27935 MW;  C5CC7232E21F11F1 CRC64;
     MKNVGDLMQR LQKMMPAHIK PAFKTGEELL AWQKEQGAIR SAALERENRA MKMQRTFNRS
     GIRPLHQNCS FENYRVECEG QMNALSKARQ YVEEFDGNIA SFIFSGKPGT GKNHLAAAIC
     NELLLRGKSV LIITVADIMS AMKDTFRNSG TSEEQLLNDL SNVDLLVIDE IGVQTESKYE
     KVIINQIVDR RSSSKRPTGM LTNSNMEEMT KLLGERVMDR MRLGNSLWVI FNWDSYRSRV
     TGKEY