ID   DNAE2_ANASK             Reviewed;        1133 AA.
AC   B4UDQ9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=AnaeK_2248;
OS   Anaeromyxobacter sp. (strain K).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter;
OC   unclassified Anaeromyxobacter.
OX   NCBI_TaxID=447217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G.,
RA   Beliaev A.;
RT   "Complete sequence of Anaeromyxobacter sp. K.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; CP001131; ACG73475.1; -; Genomic_DNA.
DR   RefSeq; WP_012526274.1; NC_011145.1.
DR   AlphaFoldDB; B4UDQ9; -.
DR   SMR; B4UDQ9; -.
DR   EnsemblBacteria; ACG73475; ACG73475; AnaeK_2248.
DR   KEGG; ank:AnaeK_2248; -.
DR   HOGENOM; CLU_001600_4_0_7; -.
DR   OMA; NSWPMGF; -.
DR   OrthoDB; 561611at2; -.
DR   Proteomes; UP000001871; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.1600; -; 1.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 2.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 2.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT   CHAIN           1..1133
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_1000188731"
SQ   SEQUENCE   1133 AA;  120939 MW;  2A018B5870C2D336 CRC64;
     MSHAPRYAEL RCKSCFSFLE GASHPEELVG RAAELGLSAL ALADVNGLYG IVRAHAEAKR
     QGLPLIVGAE LVVAGLAPGR PARLVLLAQD REGYAGLCRL VTRAHCGEGW TGAPERRERD
     AVAVPFEAVA AGARGLFALY PGADGDAVAR LKDAFGRRAA LAVARHRVAG EEARVLAARS
     AGRRLGVPVA VTNDVHTHAR ARQVLQDVLT CVRHGTTVDR AGRRLFPNAE RTLKGPEELA
     RLWSDFPEGL AAAADIADQC RFRMEAIRGE HPLPPVVVER GALAGGVEVA TSSPAQAARE
     GARTATPSLS LRASLPAERP AAPAIEGCAA SGPGLPAAGA GGGAAAAAAT DRDGALAGMS
     LLRELVREGA RWRYGGEPPE DVARQLAREL ELVESLGYAS YFLTVWDVVR FARSRGILCQ
     GRGSAANSAV CYVLGITSID PVRMGLLFER FISAERGEPP DIDVDFEHER REEVLQYVYQ
     RYGRDRAGMV CEVITYRGKS ALRDVGKALG LSLGQVDRLA KLIGTYEDLG QVGPELLAQA
     GLDAADSERV RMTLALAREL QGFPRHLSIH VGGFVITRRP LCETVPIEPA AMPGRTIVQW
     DKDDLAELDL LKVDLLGLGM LTALSRALAL LARHRPAPAS PTAVPHPDAL ATIPAEDPEV
     YEMLGRADSI GVFQVESRAQ MSLAPRLRPR NFYDLVISVA IIRPGPIQGG MIHPYLRRRD
     GKEQVRYPYA PLEPVLARTL GVPLFQEQAM RLAVIAAGFT PGEADELRRV MTHRRSHEKL
     AAMKARLVAG MAERGISGAD AEEIFKQLLG FAGYGFPESH AASFALLVYA SAWLKRYHPA
     AFACALLNSQ PMGFYAPHTL VEDAKRHGVE VRGVDVGCSG WESSLEGAAP GRPAAPGETA
     VLRVGLHAVR GLPRAVGEAI LEARAAGPFG SVAELVRRAR LSRAWLVRLA EAGALGALAP
     DRRDAVWRSL AVEADGGDLF AGLAPPEPEV ALPAASAADE VSADFATTGL SVRGHPMALV
     RPGLGGDRIR TARELGRLPD RAPVEVAGLV IVRQRPETAR GIVFVSLEDE TGIANLVVMP
     DVYERFRPVV RGAPFLLARG RVERSGKVVN VRVDSVAPLA LAPATGARAR DFH