DNAE2_ANASK
ID DNAE2_ANASK Reviewed; 1133 AA.
AC B4UDQ9;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=AnaeK_2248;
OS Anaeromyxobacter sp. (strain K).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter;
OC unclassified Anaeromyxobacter.
OX NCBI_TaxID=447217;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G.,
RA Beliaev A.;
RT "Complete sequence of Anaeromyxobacter sp. K.";
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC translesion synthesis (TLS). It is not the major replicative DNA
CC polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01902};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR EMBL; CP001131; ACG73475.1; -; Genomic_DNA.
DR RefSeq; WP_012526274.1; NC_011145.1.
DR AlphaFoldDB; B4UDQ9; -.
DR SMR; B4UDQ9; -.
DR EnsemblBacteria; ACG73475; ACG73475; AnaeK_2248.
DR KEGG; ank:AnaeK_2248; -.
DR HOGENOM; CLU_001600_4_0_7; -.
DR OMA; NSWPMGF; -.
DR OrthoDB; 561611at2; -.
DR Proteomes; UP000001871; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.1600; -; 1.
DR HAMAP; MF_01902; DNApol_error_prone; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR023073; DNA_pol_error_prone.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR004805; PolC_alpha.
DR PANTHER; PTHR32294; PTHR32294; 2.
DR PANTHER; PTHR32294:SF4; PTHR32294:SF4; 2.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; SSF89550; 1.
DR TIGRFAMs; TIGR00594; polc; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA repair; DNA replication;
KW DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT CHAIN 1..1133
FT /note="Error-prone DNA polymerase"
FT /id="PRO_1000188731"
SQ SEQUENCE 1133 AA; 120939 MW; 2A018B5870C2D336 CRC64;
MSHAPRYAEL RCKSCFSFLE GASHPEELVG RAAELGLSAL ALADVNGLYG IVRAHAEAKR
QGLPLIVGAE LVVAGLAPGR PARLVLLAQD REGYAGLCRL VTRAHCGEGW TGAPERRERD
AVAVPFEAVA AGARGLFALY PGADGDAVAR LKDAFGRRAA LAVARHRVAG EEARVLAARS
AGRRLGVPVA VTNDVHTHAR ARQVLQDVLT CVRHGTTVDR AGRRLFPNAE RTLKGPEELA
RLWSDFPEGL AAAADIADQC RFRMEAIRGE HPLPPVVVER GALAGGVEVA TSSPAQAARE
GARTATPSLS LRASLPAERP AAPAIEGCAA SGPGLPAAGA GGGAAAAAAT DRDGALAGMS
LLRELVREGA RWRYGGEPPE DVARQLAREL ELVESLGYAS YFLTVWDVVR FARSRGILCQ
GRGSAANSAV CYVLGITSID PVRMGLLFER FISAERGEPP DIDVDFEHER REEVLQYVYQ
RYGRDRAGMV CEVITYRGKS ALRDVGKALG LSLGQVDRLA KLIGTYEDLG QVGPELLAQA
GLDAADSERV RMTLALAREL QGFPRHLSIH VGGFVITRRP LCETVPIEPA AMPGRTIVQW
DKDDLAELDL LKVDLLGLGM LTALSRALAL LARHRPAPAS PTAVPHPDAL ATIPAEDPEV
YEMLGRADSI GVFQVESRAQ MSLAPRLRPR NFYDLVISVA IIRPGPIQGG MIHPYLRRRD
GKEQVRYPYA PLEPVLARTL GVPLFQEQAM RLAVIAAGFT PGEADELRRV MTHRRSHEKL
AAMKARLVAG MAERGISGAD AEEIFKQLLG FAGYGFPESH AASFALLVYA SAWLKRYHPA
AFACALLNSQ PMGFYAPHTL VEDAKRHGVE VRGVDVGCSG WESSLEGAAP GRPAAPGETA
VLRVGLHAVR GLPRAVGEAI LEARAAGPFG SVAELVRRAR LSRAWLVRLA EAGALGALAP
DRRDAVWRSL AVEADGGDLF AGLAPPEPEV ALPAASAADE VSADFATTGL SVRGHPMALV
RPGLGGDRIR TARELGRLPD RAPVEVAGLV IVRQRPETAR GIVFVSLEDE TGIANLVVMP
DVYERFRPVV RGAPFLLARG RVERSGKVVN VRVDSVAPLA LAPATGARAR DFH