ID   DNAE2_BDEBA             Reviewed;        1061 AA.
AC   Q6MQS6;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=Bd0384;
OS   Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 /
OS   HD100).
OC   Bacteria; Proteobacteria; Oligoflexia; Bdellovibrionales;
OC   Bdellovibrionaceae; Bdellovibrio.
OX   NCBI_TaxID=264462;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100;
RX   PubMed=14752164; DOI=10.1126/science.1093027;
RA   Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C.,
RA   Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E.,
RA   Schuster S.C.;
RT   "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a
RT   genomic perspective.";
RL   Science 303:689-692(2004).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; BX842647; CAE78371.1; -; Genomic_DNA.
DR   RefSeq; WP_011162973.1; NC_005363.1.
DR   AlphaFoldDB; Q6MQS6; -.
DR   SMR; Q6MQS6; -.
DR   STRING; 264462.Bd0384; -.
DR   PRIDE; Q6MQS6; -.
DR   EnsemblBacteria; CAE78371; CAE78371; Bd0384.
DR   KEGG; bba:Bd0384; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_7; -.
DR   OMA; NSWPMGF; -.
DR   OrthoDB; 561611at2; -.
DR   Proteomes; UP000008080; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0009432; P:SOS response; EXP:CollecTF.
DR   Gene3D; 2.40.50.140; -; 1.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..1061
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_0000103366"
SQ   SEQUENCE   1061 AA;  121567 MW;  C0C592AE67AB3C83 CRC64;
     MTNKALIPSQ NSRLPAKPRP RAKGFVELLG RSNFSFLQGA SSPEEMVSQA VEFGYDGMAL
     CDLNGLYGVV RGFQTIQSPS LFTASPQVKE NFHYLIGSEL TLTDESSVVL IPMNKQGYSH
     LCEILTLGKR QAAKGFSKLS LEQIEKYNQG LLCLALPPWT DERYEKLEKI FDNRLYLPLW
     RDLTWESQEF CRQGFALEEK YKAQLFVTQR PFMHSPERKP LFDVLTCTLH HTTLAEAKNK
     LIQNSERCLK SLEDISWLWQ DRLDLVEKTV EISARVTFSL NEIRYRYPAS SLPSGMTPTE
     YMRHLTLKGA ESRYPEGIPD KALKQIEHEL ELIKDLQYED YFLTLKEICD FASERKILYQ
     GRGSAANSVV CFCLGLTAID PVKMDLLFER FLSRERREPP DIDIDFEHSR REEVIQHIYE
     KYNERHAAMV CTVIRYRSRM AIRETAKVFG MPLAKINAMI KFMGRDGMKR LLDPAVAADF
     GMEPGPWKMF MALAQQLHGF PRHLGIHTGG FLITQDPITE MVPVEKATMN GRYVIQWNKD
     DVDFLRLMKI DVLSLGMLTC LRKCFDLLRD VKGRDYSLAT LPADDKPTYD MICRAETVGV
     FQIESRAQMN TLPRMQPRNF YDLVIEIALI RPGPLQGGMV HPFLKLRQNP PKEIKYAHPA
     LEPILKKTMG IPIFQEQVMK MVVAVADFTP GEADELRRVM SSAWKRKATM GGIEQRLRTG
     FARHGISSEY ADQIFKTIEG FANYGFPESH SASFALLTYA SCYLKCHYPD VFACGLLNSQ
     PMGFYAPRTI IAEAQRNGVV VAPLDVQKSD YDYTIEKTAA GDLLRVGLRS IYGIPEVLIR
     RIEDSRKEEG LYIDLADFIR RTQLPRSVLL KLAAAGAFES FNSNVRELIW NLESLSLDQQ
     SFLWGHPKEQ FELGEDDDEP EHLPFESNWD RLRREYDSKG YSVESHPMSV LRTYLHSKSE
     ALREKRFVPY FSSEDLKRMK TKTKVRVAGL VAITQRPPTA KGMCFITLED EFGFVNIVIH
     PEIYQKDRTT IYTRSLLEIH GQVEKVGAIT NIRAERILPL G