ID   DNAE2_CAUVC             Reviewed;        1083 AA.
AC   Q9A3J3;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Error-prone DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=dnaE2; OrderedLocusNames=CC_3211;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). Along with ImuA and ImuB is required for
CC       the error-prone processing of DNA lesions (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE005673; AAK25173.1; -; Genomic_DNA.
DR   PIR; A87647; A87647.
DR   RefSeq; NP_422005.1; NC_002696.2.
DR   RefSeq; WP_010921044.1; NC_002696.2.
DR   AlphaFoldDB; Q9A3J3; -.
DR   SMR; Q9A3J3; -.
DR   STRING; 190650.CC_3211; -.
DR   EnsemblBacteria; AAK25173; AAK25173; CC_3211.
DR   KEGG; ccr:CC_3211; -.
DR   PATRIC; fig|190650.5.peg.3217; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_5; -.
DR   OMA; NSWPMGF; -.
DR   BioCyc; CAULO:CC3211-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.140; -; 1.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..1083
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_0000103375"
SQ   SEQUENCE   1083 AA;  120800 MW;  124E5F216A555E64 CRC64;
     MRPPVYAELQ ATTNFSFLRG ASHAEELALT AEALGLTAIG IVDRNSLAGV VRAWTAAKRR
     SIRVLTGCRL DFMDGAPSLL CYPTDREAFG RLTRLLTIGQ LRAEKGECHL TWRDFLDHSE
     GQLGLIVPPR VLDDSFEQHL TRMAGDLRGR SWLAASRAYA ARDLQRLARL ESLGRTSGAP
     IVATNDVLYH GPERRPLQDV ISCVREHCAI QEAGFRLEAN AERHIKSPEE MARLFDRWPR
     AVERTVEIVE RIGFDLKDIR EQYPDEPVPP GKTAMQHLTD LTWKGAAWRY PNGVSPKVTA
     QIQEELRLIE KMDYPNYFIT VHDIVREARS MGILCQGRGS AANSSVCFCL GVTAIDPTEH
     RLLFTRFISE NRGEPPDIDV DFEHDRREEV MQYVFQRYGR AYAAICGTVI HYRPRSAIRD
     VGKALGLTED VTSLLAGTVW GSWGDGLPED HLRNAGLDPK APEIARAVGL ANDLIGFPRH
     LSQHVGGFVL TKRRLDETVP IGKAAMKDRT FIEWDKDDID SLGLMKVDIL ALGMLHAIQR
     AMTMLREDHG QDWLKDLADI PKEVPGVYDM LCAADSVGVF QVESRAQMSM LPRLRPREFY
     DLVIQVAIVR PGPIQGDMVH PYLKRRNKEE PVDWPKPSPE HGPPDELQEI LGKTFGVPLF
     QEQAMSLAIE AAKFTPDEAD GLRKAMATFR NLGSPDAYRN KFIEGMVGRG YERAFAERCF
     KQIEGFSHYG FPESHAASFA KLVYVSAWIK WAWPDVFCAA LINAQPMGFY QPAQLVRDAR
     EHGVEVLPPD ILTSDWDCTL APISTGFRPP RVRHDKVACQ ETRPRWKAVR LGFRQIKGLR
     ETLDIPPLLK ARGEGARTPA EFAQGGVPQK ALELLAEADA FASVGLSRRE ALWAVKGLKG
     EHKAPVQAPL LAGLPLFEER VALPAMAATQ EVAEDYRTTS LSLKAHPIGF YRSMLAARGV
     VPAERLLSLK DGARVSVAGL VLIRQRPGTA KGVVFVTLED ETGVANAVVW KDRFDAARNV
     VMTASFLIVH GRVQRADNVI HVVAERFTDL SAELSSLRDE PGAPAPRIRQ KVSGRLLRSR
     DFH