ID   DNAE2_CORJK             Reviewed;        1153 AA.
AC   Q4JTH1;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=jk1709;
OS   Corynebacterium jeikeium (strain K411).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=306537;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K411;
RX   PubMed=15968079; DOI=10.1128/jb.187.13.4671-4682.2005;
RA   Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A.,
RA   Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F.,
RA   Rupp O., Schneiker S., Viehoever P., Puehler A.;
RT   "Complete genome sequence and analysis of the multiresistant nosocomial
RT   pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the
RT   human skin flora.";
RL   J. Bacteriol. 187:4671-4682(2005).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; CR931997; CAI37886.1; -; Genomic_DNA.
DR   RefSeq; WP_011274077.1; NC_007164.1.
DR   AlphaFoldDB; Q4JTH1; -.
DR   SMR; Q4JTH1; -.
DR   STRING; 306537.jk1709; -.
DR   PRIDE; Q4JTH1; -.
DR   EnsemblBacteria; CAI37886; CAI37886; jk1709.
DR   KEGG; cjk:jk1709; -.
DR   PATRIC; fig|306537.10.peg.1730; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_11; -.
DR   OMA; NSWPMGF; -.
DR   OrthoDB; 561611at2; -.
DR   Proteomes; UP000000545; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR004805; PolC_alpha.
DR   InterPro; IPR010994; RuvA_2-like.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 2.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..1153
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_0000103379"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          64..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1153 AA;  124693 MW;  ABA8D590EEB42173 CRC64;
     MFYSCCVSIE PRDPASEPTP TPRRPLRKSQ PRSFSQAQPL SWAQLESVLS GRGAGLRNLR
     AVGVGEGQRR TTSLDPAEAE GTGAEGASQK GITTPFAELH ASSAYNFLRG ASQPEQMVEA
     ARELGLSALA CVDRDGFYGA ARFATAVAES GADLATVFGA ELSLDVPLTV LCKGREGYTR
     LSRVIADARM ADPDKDSVRY PSLPQLAEAA GGHWLVLLDW RRTDAQLVDF FGADNVVVEL
     QHTMNPADAD RNERLHALAV RHGLREIVSS APTCATPKHS RLAGAKAALR ERKDMAAAEP
     TTHPVGGSWL RSGEEMLQLA GDCEWLARAV ETSVQVAEEC AFTLDLVAPN LPHFPVPEGY
     TEMTWLRAIT ERGGAQRYGP RGSSAAANQA WATIDRELET IEQLGFPGYF LIVHDIVSFC
     HENNIFCQGR GSAANSAVCF ALGITTVDAV ASGLLFERFL SPERDGPPDI DLDIESGRRE
     EAIQYVYSRY GRENAAQVAN VITYRRRGAT RDAGRALGYA PGQIDAWTRH PEQTPDVVQN
     LAEQMLDHPR HLGIHSGGMV ICDRPIAQVV PTEWARMEGR SVVQWDKDDC AAVGLVKFDL
     LGLGMLEALH HAVDQVRAHR GREVELWRLD PTESEVYAML SRADAVGVFQ VESRAQMSTL
     PRLKPRTFYD LVVEVALIRP GPIQGGSVHP YIRRRNGLEP VTFDHPCLEP ALTKTLGIPL
     FQEQLMQMAV DAAGFSGAEA DTLRRAMGSK RSPQKMERLK KRFYQGLEAK NGIRGVVADR
     LWDKIVAFAS YGFPESHSQS FASLVYYSAW FKYHYPAEFC VALLRAQPMG FYSPQSLLAD
     ARRHGVEVLP VDVNDSDVQV DAVASLATPP RTNRPTGVHG LGRGTGEPVG QIRLGLSGAG
     GVKGISAEVA ERIVEARERI GRFTSVEDLS REAGLTVAHV EKLARAGALG SLGLTRRQAV
     WAAGVAATER PGMLPGTSGV HAPALPGMSA FEMVASELAT TGVTTAEHPV QLLREYLDEW
     HLRPAPRGVH PGDAAPRGGA AVVTADSLLR VPDGTRVRVA GVVTHRQRPA TAGGVVFFGL
     EDETGLANIV VSQGLWARQR AVALNAKILV VRGIVHNAEG AATVTADLLE QVETQLRPAG
     EIAGAHAGSR DFR