ID   DNAE2_GLUOX             Reviewed;         901 AA.
AC   Q5HXU1;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Error-prone DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=dnaE2; OrderedLocusNames=GOX2598;
OS   Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans).
OG   Plasmid pGOX1.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Gluconobacter.
OX   NCBI_TaxID=290633;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=621H;
RX   PubMed=15665824; DOI=10.1038/nbt1062;
RA   Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F.,
RA   Ehrenreich A., Gottschalk G., Deppenmeier U.;
RT   "Complete genome sequence of the acetic acid bacterium Gluconobacter
RT   oxydans.";
RL   Nat. Biotechnol. 23:195-200(2005).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000004; AAW59662.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5HXU1; -.
DR   SMR; Q5HXU1; -.
DR   STRING; 290633.GOX2598; -.
DR   EnsemblBacteria; AAW59662; AAW59662; GOX2598.
DR   KEGG; gox:GOX2598; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_5; -.
DR   OMA; VAKSHHW; -.
DR   Proteomes; UP000006375; Plasmid pGOX1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Plasmid;
KW   Reference proteome; Transferase.
FT   CHAIN           1..901
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_0000103380"
SQ   SEQUENCE   901 AA;  100168 MW;  56F6240D81383D72 CRC64;
     MAMYCEPRSE WWTRLPAPGG HRAWIACSSA LSRSAVLAGT PARLPVSTSA FLTHSFSVCA
     EQPILLAIDT IAVQRDGCSP SCSRTRRTAR ERTSGENFFT GLLIRPSSQV NRSPLIPGRF
     NPTETERTGE SAQETLTRLV QAALPRRYPA GAPPEVETQI AHELRLIGSL SYAPYFLTVN
     TIVRHARSLG IVCQGRGSAA NSAVCYVLGI TSIDPVRSGL LFERFISTER QEPPDIDVDF
     ESDRREEVIQ WIYRHYGRHR AALCATVQRY QPKGALREVG KVLGLPEDLT GQLSKHIASS
     LADPDLCKAR AADLGLNLKD RRLSLTFHLA RLLLGFPRQL GTHPGGFVLT EDRLDELVPL
     MPTAMDGRQI IVWDKDDIDV LRFMKVDVLG LGMLGCLRRG FELLHTVYQT RMDLAAIPAE
     DPQTYRMVQK ADTLGTFQIE SRAQMSMLPR MKPATFYDLV IQVAIVRPGP IQGDMVHPYL
     RRREKLEPVT YPSETLRGIL GKTLGVPLFQ EQAMQVAIHC AGFTPGEADQ LRRAMATFKM
     TGGVSPFRDK LVNGMLANGY EQEFAEQTFA QLEGFGSYGF PESHAASFAL IAYASAWMKC
     HYPDVFCAAL LNSQPMGFYA PSQIVQDAQR HGVEVRPICI NASRWDCTLE RGRNGRHAAV
     RLGFRMVKGL ANGHGAALIA ARMPDYESID DVWRRADVPV AALKCLAEAD AFRVFGQMRR
     AALWSIKGLA DTALPLFEAA DRGRNFPLPE VIEPEITLPM MSERASVHED YRATGLSLNG
     HPVAFLREGL RKEGIVRCGD LPYLRDGRRI QLTGLVLMRQ RPGTANGTMF VTIEDETGTA
     NLIVWKDVQE KYRRPLLASR LLACKGRLQK EGDVIHVVVL SLEDRTPLLQ GSEPLKARDF
     R