ID   DNAE2_HAHCH             Reviewed;        1032 AA.
AC   Q2SJZ6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=HCH_02200;
OS   Hahella chejuensis (strain KCTC 2396).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Hahellaceae; Hahella.
OX   NCBI_TaxID=349521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCTC 2396;
RX   PubMed=16352867; DOI=10.1093/nar/gki1016;
RA   Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G.,
RA   Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K.,
RA   Oh T.K., Kim J.F.;
RT   "Genomic blueprint of Hahella chejuensis, a marine microbe producing an
RT   algicidal agent.";
RL   Nucleic Acids Res. 33:7066-7073(2005).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; CP000155; ABC29028.1; -; Genomic_DNA.
DR   RefSeq; WP_011396097.1; NC_007645.1.
DR   AlphaFoldDB; Q2SJZ6; -.
DR   SMR; Q2SJZ6; -.
DR   STRING; 349521.HCH_02200; -.
DR   EnsemblBacteria; ABC29028; ABC29028; HCH_02200.
DR   KEGG; hch:HCH_02200; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_6; -.
DR   OMA; NSWPMGF; -.
DR   OrthoDB; 561611at2; -.
DR   Proteomes; UP000000238; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.140; -; 1.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..1032
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_1000073690"
SQ   SEQUENCE   1032 AA;  117543 MW;  9D5BC44F91C8D5C2 CRC64;
     MSFVELHCIS NYSFLKGASH PEELVRQAIA QGYEGLAITD ECSVAGAVKA WRELRRLRQE
     APEASAFKLI IGSEFHYEGN CFVVLAPHKK AYGELCRFIT DCRRKADKGD YQFSPDALNE
     NIKQGLLLWR PKQSDQEFIP ALTKIFSGRL WLLLELSLSE EDDSERELIQ TLSSAYNLPV
     VSSNGVKMHA PERKRLHDAL TAIRFNQSVD SIKDRLAPNA ENYLRPLNEI HEIYPSFTIQ
     ESLRIAAKCA FELNEIRYQY PKEVVPEGDD PSAYLRRLTY EGAHLRYPQG IPENVLATLE
     KELNIISELQ YEYYFLTIFD IVDYAKKSQI LCQGRGSAAN SVVCYCLGIT AVDPTRASLL
     FERFISKGRD EPPDIDVDFE NARREEVIQY LYRRYGRERC AIAATVITYR PKSAIRDLGK
     ALGVDLLQLE SVIANYGWRY RGQDWIDEVI TPQVSQDNHI LTCFKELLPE LLGFPRHLSQ
     HVGGFVLSAG PLVELVPIEN AAMEDRTVIQ WDKDDLESLG LMKVDVLALG MLTALKKCTT
     YISEITGKTF SLESIPKEED SQVYDMLQRA DTVGLFQVES RAQMNMLPRL RPEKYYDLVV
     QVAIVRPGPI HGDMVHPYLR RRHNLEDPDD VPLPELKPIL KRTFGVPIFQ EQVIAIAIVG
     AGFTSEEAEE LRRSMASWKR RGHMGKLMDK LIINLLKKGV PLEYIQRLCR QIEGFGEYGF
     PESHAASFAL LAYHSGWLKY YYPSAFCCAL LNSQPMGFYA PWQVIQDAQR HGVIVLPVDI
     NNSYWEHRLE PHSDNTKEGA LRLGFRLVKG LSEEAACSII QHRTDEGFTS LVQVMHLPKI
     NREDLEALAS ANALASLGEN RYQQRWECSG FLYYYQLFSE CEYINIDFEP PSRLDNIYED
     HSSTGVVLND HPLAYLREAN LTPQCLTAVE LLKQKAGLKT YVAGVVINRQ RPKTSTGVTF
     VTLEDETGSI NILVWKKTAI AQMDILVKAR LLMVYGELDK DEEGRVAHVL AHRLTDLTPH
     LEELESRSRD FH