ID   DNAE2_MYCPA             Reviewed;        1093 AA.
AC   Q73U92;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=MAP_3476c;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016958; AAS06026.1; -; Genomic_DNA.
DR   RefSeq; WP_003879017.1; NC_002944.2.
DR   AlphaFoldDB; Q73U92; -.
DR   SMR; Q73U92; -.
DR   STRING; 262316.MAP_3476c; -.
DR   EnsemblBacteria; AAS06026; AAS06026; MAP_3476c.
DR   KEGG; mpa:MAP_3476c; -.
DR   PATRIC; fig|262316.17.peg.3697; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_11; -.
DR   OMA; NSWPMGF; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..1093
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_0000103384"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1093 AA;  118223 MW;  9AB2F22EFD7BFF35 CRC64;
     MGWFNGPPSW AEMERVLDSK PRRAGESAAP EPDGPLSRGR ATYRPPDEGR AARSSVPYAE
     LHAHSAFSFL DGASTPEEMV EEAARLDLRA LALTDHDGLY GAVRFAEAAA ELDVRTVFGA
     ELSLGPSART EAPDPPGPHL LVLARGPEGY RRLSRQLAAA HLAGGEKGKP RYDLDALTEA
     AGGHWHILTG CRKGHVRQAL SDGGPDAAAR ALADLVDRFG AARVSIELTR HGQPLDDERN
     AALAALAPRF GVGVVATTGA HFAGPSRRRL AMAMGAIRAR ESLDSAAGWL APLGGSHLRS
     GAEMARLFAW RPQAVTAAAE LGEQCAFGLA LIAPRLPPFD VPDGHTEDSW LRQLTMTGAR
     DRYGSPEHAP RAYAQIEHEL KVIAQLQFPG YFLVVHDIAR FCRENNILCQ GRGSAANSAV
     CYALGVTAVD PVANELLFER FLSPARDGPP DIDMDIESDQ REKVIQYVYD RYGRDYAAQV
     ANVITYRGKI AVRDMARALG YSQGQQDAWS KQISSWSGPA DSPDVEGIPP QVIDLANQVR
     NLPRHLGIHS GGMVICDRPI ADVCPVEWAR MENRSVLQWD KDDCAAIGLV KFDLLGLGML
     SALHYAIDLV AEHKGIEVDL ARLDLSEPAV YEMLARADSV GVFQVESRAQ MATLPRLKPR
     VFYDLVVEVA LIRPGPIQGG SVHPYIRRRN GVDPVLYDHP SMEPALRKTL GVPLFQEQLM
     QLAVDCAGFS AAEADQLRRA MGSKRSTERM RRLRSRFYDG MRALHGAPDE VIDRTYEKLE
     AFANFGFPES HALSFASLVF YSSWFKLHHP AAFCAALLRA QPMGFYSPQS LVADARRHGV
     TVHGPDVNAS LAHATLENAG TEVRLGLGAV RHIGDDLAEK LVQERKANGP FTSLLDLTAR
     LQLSVQQTEA LATAGAFGCF GMSRREALWA AGAAATQRPD RLPGVGSSSH IPALPGMSEL
     ELAAADVWAT GISPDSYPTQ FLRDDLDAMG VVPAARLGSV PDGDRVLIAG AVTHRQRPGT
     AQGVTFLNLE DETGMVNVLC TPGVWARHRK LANTAPALLV RGQVQNASGA ITVVAERLGR
     ITLAVGSRSR DFR