ID   DNAE2_PSEA7             Reviewed;        1024 AA.
AC   A6VAU7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=PSPA7_4841;
OS   Pseudomonas aeruginosa (strain PA7).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=381754;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PA7;
RA   Dodson R.J., Harkins D., Paulsen I.T.;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; CP000744; ABR84074.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6VAU7; -.
DR   SMR; A6VAU7; -.
DR   EnsemblBacteria; ABR84074; ABR84074; PSPA7_4841.
DR   KEGG; pap:PSPA7_4841; -.
DR   HOGENOM; CLU_001600_4_0_6; -.
DR   OMA; NSWPMGF; -.
DR   Proteomes; UP000001582; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT   CHAIN           1..1024
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_1000070592"
SQ   SEQUENCE   1024 AA;  114629 MW;  8801214E9DE8C2F5 CRC64;
     MSAYAELHCL SNFSFQRGAS SAAELFARAA RLGYRALAIT DECSLAGIVR AWQAAREYRV
     KLLVGSEIRL EQGPKLVLLA EDLAGYQQLC RLITRGRRRA DKGSYRLLRE DLQPALDGVL
     AIWLAEPGDD DDAAWLGECF PQRLWLGVEL HRGADDDARL RGLLALAARA QLPAVACGDV
     HMHCRGRRAL QDCMTAIRNH LPVSEAGAHL FANGERHLRP LAALQGIYPE ALLAETLRIA
     ERCRFDLEQL KYQYPRELVP AGHDPASWLR RLTEKGIRRR WPDGASAKVR EQIEKELKLI
     SELGYESYFL TVQDIVGFAR RQKILCQGRG SAANSAVCFA LGITELDPER INLLFERFLS
     RERNEPPDID VDFEHERREE VIQYVFNRYG RQRAALTAVV STYHGAGAVR DVAKALGLPP
     DQVDALANCC GRWSDRAPSA ERLMEAGFDP QSAVLRRVLA LTGELVGFPR HLSQHPGGFV
     ISEQPLDTLV PVENASMVER TVIQWDKDDL DAVGLLKVDV LALGMLSALR RSFDLLHELR
     GGERLSLASI PSEDPATYAM ISRADTIGVF QIESRAQMAM LPRLRPEKFY DLVIQVAIVR
     PGPIQGDMVH PYLRRRNGEE PVAYPSVELE KVFERTLGVP LFQEQVMELA IVAADYSPGE
     ADELRRSMAA WKRHGGLEHH RERLTRGMLA NGYEADFAAR IFEQIKGFGS YGFPESHAAS
     FALLTYASSW LKRHEPAAFA CALINSWPMG FYSPDQLLQD ARRHAIQTRP VDVRHSRWDC
     SLEPIGQEQP AIRLGLRMIR GFREEDARRI EQARQAQSFT DVHDLGRRAG LDTRALELLA
     DAGALRGLAG HRHKARWAIA GVEPQLPLFA EGPRIEEPAI SLPLPSRGEE LLSDYALLGT
     TLGPHPLKLL RVQLKARRCR ASRELVGMEH GRPVRIAGLV VGRQRPQTAS GVTFITLEDE
     FGMVNVVVWH DLAERQRRPF LESRLLQVEG TLESSSGVRH VIAGRLQDLT PLLTGLDVRS
     RDFH