ID   DNAE2_PSEU2             Reviewed;        1031 AA.
AC   Q4ZTG0;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=Psyr_2523;
OS   Pseudomonas syringae pv. syringae (strain B728a).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX   NCBI_TaxID=205918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B728a;
RX   PubMed=16043691; DOI=10.1073/pnas.0504930102;
RA   Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A.,
RA   Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S.,
RA   Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M.,
RA   Kyrpides N.C., Ivanova N., Lindow S.E.;
RT   "Comparison of the complete genome sequences of Pseudomonas syringae pv.
RT   syringae B728a and pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; CP000075; AAY37562.1; -; Genomic_DNA.
DR   RefSeq; WP_011267744.1; NC_007005.1.
DR   RefSeq; YP_235600.1; NC_007005.1.
DR   AlphaFoldDB; Q4ZTG0; -.
DR   SMR; Q4ZTG0; -.
DR   STRING; 205918.Psyr_2523; -.
DR   PRIDE; Q4ZTG0; -.
DR   EnsemblBacteria; AAY37562; AAY37562; Psyr_2523.
DR   KEGG; psb:Psyr_2523; -.
DR   PATRIC; fig|205918.7.peg.2584; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_6; -.
DR   OMA; NSWPMGF; -.
DR   Proteomes; UP000000426; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT   CHAIN           1..1031
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_0000103391"
SQ   SEQUENCE   1031 AA;  116142 MW;  21A85A477C7FC6E8 CRC64;
     MTREYAELHC LSNFSFQRGA SSARELFERA LRHGYKALAI TDECTLAGIV RAWQASKSTG
     LPLIVGSEMH IENGPKVVLL VENQAGYEAL CKLITVARRR AGKGEYRVLR EDFEPAPDGL
     LALWLPDLDG NAQACLAGGR WLRERFAERL WLGVGLHRGP DDEQRLADLL ALAQSLGVPA
     VASGDVHMHA RGRRALQDTM TAIRHHTTVA EAGHLLFANG ERHLRPLDAL SEHYPDWLLA
     ESVRIARRCT FDLGDLKYEY PHELVPKGQT STSWLRELTE RGVRRRWPGG LTPATRAQVE
     KELALIAEKK FDSYFLTVHD IVEFARSQHI LCQGRGSAAN SAVCYALGIT ELNPEQSNLL
     FERFISRERN EPPDIDVDFE HDRREEVIQY IFRRYGRGRA ALTAVASTYH GSGAMRDVAK
     VLGLPPEQIN ALAEAFSRWS DSLPSPERLR EYGFDADTPI LKRVLALTGE LIGFPRHLSQ
     HPGGFVISEH PLETLVPVEN AAMADRTIIQ WDKDDLDLVG LLKVDILALG MLSALRRTFD
     LVHLHRGQRW TLATLPGDDR KTYEMISRAD TIGVFQIESR AQMAMLPRLR PEKFYDLVIE
     VAIVRPGPIQ GDMVHPYLRR RNGEEDVTYP PKLESVFKRT LGVPLFQEQV MEVAILAADY
     TPGEADELRR AMAAWKRHGG LEPHRERLRT GMLKNGYEAD FADRIFEQIK GFGSYGFPES
     HAASFALLTY ASCWLKCHEP AAFTCALINS WPMGFYSPDQ LLQDARRHHI EIRPVDVRYS
     DWDCSLEPLD HPDRTRNLAI RLGLRMVRSF REEDALRIEV ARAKRPFVDA TDLTLRAELD
     ARAAEALADS GALRGLIGHR HRARWEVAGV EAQRPLFDDL PSEETQVTLP LPTVAEDLVA
     DYTTLGTTLG PHPLALLRRQ LAAKRFRSSQ DLLHLENDRT LSVAGLVIGR QRPGTASGVT
     FVTLEDEFGM VNVVVWRDLA ERQRKVLVGS QLLQVFGRLE SKSGVRHLIA QRLYDLTPLL
     TGLDVRSRDF Q