ID   DNAE2_RHOBA             Reviewed;        1145 AA.
AC   Q7UXK9;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=RB1262;
OS   Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1).
OC   Bacteria; Planctomycetes; Planctomycetia; Pirellulales; Pirellulaceae;
OC   Rhodopirellula.
OX   NCBI_TaxID=243090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10527 / NCIMB 13988 / SH1;
RX   PubMed=12835416; DOI=10.1073/pnas.1431443100;
RA   Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W.,
RA   Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R.,
RA   Reinhardt R.;
RT   "Complete genome sequence of the marine planctomycete Pirellula sp. strain
RT   1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; BX294135; CAD71997.1; -; Genomic_DNA.
DR   RefSeq; NP_864318.1; NC_005027.1.
DR   AlphaFoldDB; Q7UXK9; -.
DR   SMR; Q7UXK9; -.
DR   STRING; 243090.RB1262; -.
DR   PRIDE; Q7UXK9; -.
DR   EnsemblBacteria; CAD71997; CAD71997; RB1262.
DR   KEGG; rba:RB1262; -.
DR   PATRIC; fig|243090.15.peg.577; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_0; -.
DR   InParanoid; Q7UXK9; -.
DR   OMA; NSWPMGF; -.
DR   OrthoDB; 561611at2; -.
DR   Proteomes; UP000001025; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..1145
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_0000103397"
SQ   SEQUENCE   1145 AA;  128627 MW;  10FAB7E2DB99B878 CRC64;
     MCSWRCAAAR SHASANRCTP KERLGRQENR SAHCPGTIRS IRMEWSRWER QEFRCKRSFQ
     RLGSSCEQFS PPMQNRRWEI ERLPWRFSPV GKPFHFRDNV RAMRYVELHC RSNFSFLDGA
     SHPDELVQRA AELGYEGLAI TDRESIAGVV RGFSPAQELG LQYIVGTEVH PTDAPPMVLW
     PTDRAAYGRM CRMLSTGRMR CEKGRCELSF EDIAEHAQGI LAGVIATDES RSIEDQHAHV
     NDSRQFLRGP FRDVFDDRGY LLASFHRGVD DAAKATWLRN LSLATDVPLL ACGDVRYHSA
     ERMALHDCVV AISQGKSVEQ IQSDRLVNSQ HHLRSLEEIA ELYRDVPDAV ARTIEVAQRC
     TFTLDQLKYE YPVELAPEGM TPIEHLKRLT WEGARGRWPN GVPEKVIETL RHEVTLIEDL
     QYEAYFLTVW DLVRFARSQE ILCQGRGSAA NSVVCYCLGI TSVDPTHTDL LFERFISRER
     GEAPDIDVDF EHQRREEVLQ YLYEKYGRDR AGMTAVVTCY RAKSAIREVG KALAISPDII
     DAVAKLAGSY SRNPELPERC RDAGLDPDTP LGRRFLYLTE TLIGFPRHLS QHVGGMVMTA
     GSLCELCVTE NAAMPGRSVI QWNKDDLDDI GILKVDILAL GMLSAIRRCF ELVKDHHNRE
     LSLSTIPPDD TPTYDMICAA DTMGVFQIES RAQMSMLPRL KPRCYYDLVI EVAIVRPGPI
     QGNMVHPFLA ARENPAAAKY PNDAIRKVLE KTLGVPIFQE QAMKLAVVAA GFTPGEADQL
     RRAMAAWRRP GVIDRFRTKL LEGMKANGLN GEFAENVFRQ IRGFGEYGFP ESHAASFALL
     VYASCYLKRH YPTAFCAALL DSQPMGFYAP AQLIRDAQQH GVQVLPVDIN DSNIRSKLIP
     DLNRPHPKLR LGLQMVRGLP SAVAQKIIVA RDANGPFANL HDLTTRAKLS RSNIATLADA
     DALASIAQDR RAAVWQSLAQ DDSGDSMPLL ADLEPDCSVP EELVPMSPAE EVKNDYATTG
     LSLKAHPVSF WRDDLNALRC KRASDLPKLR DGVHVRVAGL VLMRQRPGTA KGITFVTMED
     ETGSMNLVLF AQVWKRFFKI ARGSDAWIVD GKLENKKGVI HVIVGRVEDL SEKASGLKVP
     RRDFR